Background: The study was conducted to analyse of the effect of autologous Platelet Rich Plasma (PRP) in Myringoplasty.

Methods: This prospective study was conducted at Rajah Muthiah Medical college hospital in the department of otorhinolaryngology, from October 2016 to September 2018, among 20 patients who presented to the hospital with symptoms and signs suggestive of chronic otitis media. The management of the disease with myringoplasty using platelet rich plasma was studied and postoperative graft uptake and improvement in hearing were studied.

Results: The mean age group was 32.1 years. The graft uptake was successful in all patients in whom platelet rich plasma was used in myringoplasty. There was hearing improvement of at least 10 dB in 85% of the patients.

Conclusion: Platelet rich plasma with its various growth factors, has the property of tissue bio stimulation which significantly improves post-operative graft uptake in myringoplasty.

Keywords: Myringoplasty, platelet rich plasma, Tympanic membrane.

1. Al-Khtoum N, Hiari MA. Myringoplasty in children: retrospective analysis of 35 cases. Braz J Otorhinolaryngol 2009;75:371–4
2. RG, Gassmann CJ, Campbell MS. Platelet-rich plasma: properties and clinical applications. J Lanc Gen Hosp 2007;2:73–7
3. Jahn AF. Chronic otitis media: diagnosis and treatment. Med Clin North America, 1991, 75 (6): 1277-1291.
4. Chandarana, K. Fung, J. H. Franklin, T. Kotylak, D. B. Matic,and J. Yoo, “Effect of autologous platelet adhesives on dermal fat graft resorption following reconstruction of a superficial parotidectomy defect,” Head and Neck, vol. 31, no. 4, pp. 521–530, 2009
5. Y. Farrag, M. Lehar, P. Verhaegen, K. A. Carson, and P. J.Byrne, “Effect of platelet rich plasma and fibrin sealant on facialnerve regeneration in a rat model,” Laryngoscope, vol. 117, no.1, pp. 157–165, 2007.
6. C. Falc˜ao, A. R. D. B. Coelho, and J. E.Neto, “Biomechanical evaluation of microbial cellulose (Zoogloea sp.) and expanded polytetrafluoroethylene membranes as implants in repair of produced abdominal wall defects in rats,” Acta CirurgicaBrasileira, vol. 23, no. 2, pp. 184–191, 2008
7. Bielecki TM, Gazdzik TS, Arendt J, Szczepanski T, Kro´ l W, Wielkoszynski T. Antibacterial effect of autologous platelet gel enriched with growth factors and other active substances: an in vitro study. J Bone Joint Surg2007;89:417–20
8. Tate KS, Crane DM. Platelet rich plasma grafts in musculoskeletal medicine. J Prolother2010;2:371–6
9. El-Anwar, M. W., El-Ahl, M. A., Zidan, A. A., & Yacoup, M. A. (2015). Topical use of autologous platelet rich plasma in myringoplasty. Auris Nasus Larynx,42(5), 365-368. doi:10.1016/j.anl.2015.02.016
10. Ebrahim, A., Fouad, Y., Ali, M., & El-Baz, S. (2018). Myringoplasty Of Central Tympanic Membrane Perforation With A Fat Graft From The Ear Lobule And Platelet Rich Plasma. Zagazig University Medical Journal, 24(2), 143-149. doi:10.21608/zumj.2018.13088
11. Sharma D, Mohindroo S, Azad RK. Efficacy of platelet rich fibrin in myringoplasty. Int J Otorhinolaryngol Head Neck Surg2018;4:677-81
12. Smith RG, Gassmann CJ, Campbell MS. Platelet-rich plasma: properties and clinical applications. The Journal of Lancaster General Hospital 2007; 2 [2]: 73-77.

Yoganathan Gnanavelu

Department of Otorhinolaryngology, Rajah Muthiah Medical College, Chidambaram

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