Title: Association of non-Alcoholic Fatty Liver Disease with Coronary Artery Disease Risk Factors and between Severity of non-Alcoholic Fatty Liver Disease with Coronary Artery Disease among type II Diabetes Mellitus Reported at Tertiary care Hospital, Jaipur
Authors: Krishan Kumar Meena, Rajveer Bainiwal, Sudhir Bhandari, Vishal Gupta
DOI: https://dx.doi.org/10.18535/jmscr/v6i10.186
Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) has proven strong association with metabolic syndrome and it can be associated with coronary artery disease risk factors. This study was conducted to establish the association between non-alcoholic fatty liver disease and coronary artery disease risk factors and assessing the relationship between severity of NAFLD and presence of coronary artery disease (CAD) in patients of type 2 diabetes mellitus. So that it can be used as tool in preventing future CAD events in type 2 diabetic patients.
Methods: Ultrasonography was used to detect fatty liver among 340 type 2 diabetic subjects. The study group was divided into two groups: Type 2 diabetes mellitus patients with NAFLD and Type 2 diabetes mellitus patients without NAFLD. On selection, proper history and clinical examination were done regarding demographics, cardiovascular, hepatic and renal disease, drug use, smoking and alcohol consumption. Presence of coronary artery disease was defined by history of CAD medications, ECG changes, echocardiographic findings. Qualitative data expressed as number and percentage or proportion and analyzed using chi-square test. Quantitative data will be expressed as mean ± S.D and analyzed using unpaired t-test and statistical significance will be set at P< 0.05. Statistical analysis was done using software Epi info version 7.2.1.0.
Results: Coronary artery disease and its risk factors were more prevalent in NAFLD group than in Non NAFLD group. Occurrence of CAD in NAFLD patients is grade dependent i.e. as the severity of NAFLD increases the chances of occurrence of CAD also increases(p<0.001).
Conclusion: Presence of NAFLD in the type 2 diabetes patients can be associated with coronary artery disease risk factors and occurrence of CAD among type 2 diabetes patients with NAFLD depends on severity of fatty liver.
Keywords: Non-Alcoholic Fatty Liver Disease; Coronary Artery Disease; Type 2 Diabetes mellitus.
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