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Category: Volume 06 Issue 10 October 2018
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Title: A Comparative Study of Serum Vitamin D levels in Type 2 Diabetes Mellitus Patients and Age Matched controls

Authors: Balaji.I, N. Paari, S. Balasubramaniyan, C. Subathra, K. Haynes Raja

 DOI: https://dx.doi.org/10.18535/jmscr/v6i10.183

Abstract

Background: Diabetes mellitus is one of the rapidly emerging non-communicable diseases worldwide. This study is done to the assess the vitamin D deficiency existing among the fast growing diabetic population.

Aim: To compare serum vitamin D levels in type 2 diabetes mellitus patients with age matched non diabetic population and to correlate vitamin D levels with the glycemic control and duration of diabetes.

Materials and Methods: This is a hospital based case control study conducted between November 2016 and August 2018. 50 diabetic subjects and 50 age matched non diabetic controls were included in the study. Serum levels of 25(OH)-vitamin D and glycated haemoglobin were measured in both groups.

Results: Mean age group among cases and control were 48.02 ± 9.01 years and 48.20 ± 8.90 years.The mean concentration of vitamin D in the case group was 16.8±7.96ng/dl and in the control group was 21.4±11.8 ng/dl. In diabetic patients, vitamin D level was deficient in 41 (82%), insufficient in 5(10%) and sufficient in 4(8%) patients. In the non diabetic group, these parameters were seen in 33(66%), in 7(14%) and in 10 (20%) respectively. Among diabetic patients, vitamin D level had a significant inverse correlation with patient’s glycated hemoglobin levels.

Conclusion: Vitamin D deficiency was significantly high in diabetic patients than the age matched non diabetic individuals. Also Vitamin D levels were much lower among patients with poor glycemic control.

Keywords: Diabetes mellitus, serum Vitamin D, glycated haemoglobin.

References

  1. Wild S, Roglic G, Green A, Sicree R, King H. Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care. 2004 May 1;27(5):1047–53.
  2. Wang H, Chen W, Li D, Yin X, Zhang X, Olsen N, et al. Vitamin D and Chronic Diseases. Aging Dis. 2017 May;8(3):346–53.
  3. Heaney RP. Vitamin D in Health and Disease. CJASN. 2008 Sep 1;3(5):1535–41.
  4. Nair R, Maseeh A. Vitamin D: The “sunshine” vitamin. Journal of Pharmacology and Pharmacotherapeutics. 2012 Apr 1;3(2):118.
  5. Lips P, Eekhoff M, van Schoor N, Oosterwerff M, de Jongh R, Krul-Poel Y, et al. Vitamin D and type 2 diabetes. The Journal of Steroid Biochemistry and Molecular Biology. 2017 Oct 1;173:280–5.
  6. Maddaloni E, Cavallari I, Napoli N, Conte C. Vitamin D and Diabetes Mellitus. Vitamin D in Clinical Medicine. 2018;50:161–76.
  7. Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Analysis. J Clin Endocrinol Metab. 2007 Jun 1;92(6):2017–29.
  8. Nuttall FQ. Body Mass Index. Nutr Today. 2015 May;50(3):117–28.
  9. Nanda S. evaluation-of-vitamin-d-status-and-its-correlation-with-glycated-haemoglobin-in-type-2-diabetes-mellitus. Biomed Res. 2017;28(1):5.
  10. Daga RA, Laway BA, Shah ZA, Mir SA, Kotwal SK, Zargar AH. High prevalence of vitamin D deficiency among newly diagnosed youth-onset diabetes mellitus in north India. Arquivos Brasileiros de Endocrinologia & Metabologia. 2012 Oct; 56(7):423–8.
  11. Laway BA, Kotwal SK, Shah ZA. Pattern of 25 hydroxy vitamin D status in North Indian people with newly detected type 2 diabetes: A prospective case control study. Indian Journal of Endocrinology and Metabolism. 2014 Sep 1;18(5):726.
  12. Dalgård C, Petersen MS, Weihe P, Grandjean P. Vitamin D status in relation to glucose metabolism and type 2 diabetes in septuagenarians. Diabetes Care. 2011 Jun;34(6):1284–8.
  13. Buhary BM, Almohareb O, Aljohani N, Alrajhi S, Elkaissi S, Sherbeeni S, et al. Association of Glycosylated Hemoglobin Levels With Vitamin D Status. J Clin Med Res. 2017 Dec;9(12):1013–8.
  14. Sheth JJ, Shah A, Sheth FJ, Trivedi S, Lele M, Shah N, et al. Does vitamin D play a significant role in type 2 diabetes? BMC Endocr Disord. 2015 Feb 26;15:5.
  15. Sabherwal S, Bravis V, Devendra D. Effect of oral vitamin D and calcium replacement on glycaemic control in South Asian patients with type 2 diabetes. International Journal of Clinical Practice. 2010 Jul 1;64(8):1084–9

Corresponding Author

Dr N. Paari, M.D.

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