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Category: Volume 06 Issue 10 October 2018
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Title: Neutrophil Lymphocyte Ratio (NLR) in Patients with Lung Cancer - An Index of Cancer Related Systemic Inflammation

Authors: Raseela Karunakaran, Santhosh Surendran, Mithun Harold Thomas

 DOI: https://dx.doi.org/10.18535/jmscr/v6i10.181

Abstract

Introduction: Neutrophilia has been associated with many chronic inflammatory lung diseases, lung cancer and systemic inflammatory diseases. A common denominator of inflammation in these entities is Th 17 type of CD4+T cell adaptive immunity. Neutrophil infiltration of tumour microenvironment and peripheral blood neutrophilia has become a focus of attraction in recent research on chronic inflammatory diseases. Many studies have shown that increased neutrophil:lymphocyte ratio(NLR)  and advanced lung cancer inflammation index (ALI) are poor prognostic indicators in cancers.

Aims: This study aims to find out the neutrophil: lymphocyte ratio in lung cancer patients.

Materials and Methods: This study is a retrospective analysis conducted in the Department of Pulmonary medicine in a tertiary care centre in south Kerala. The case records of 50 patients, histologically diagnosed as lung cancer were analysed. NLR was calculated from routine blood examination results.

Results: The total number of patients included in the study was 50.The most common histological type of lung cancer was adenocarcinoma in both males and females of all ages. Neutrophil lymphocyte ratio was high in all patients, irrespective of the histological type. Mean value of NLR was 5.33  (reference range, 2.15 or less) (1)

Conclusion: This study shows that neutrophils are the predominant leukocytes in peripheral blood of lung cancer patients, supporting the concept of ongoing injury and repair processes in the pathogenesis of inflammation in lung cancer. NLR is a simple and inexpensive bed side biomarker of systemic inflammation in lung cancer patients.

Keywords: Lung cancer, neutrophil, lymphocyte, NLR.

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Corresponding Author

Mithun Harold Thomas

Senior Resident, Department of Gastroenterology, Government Medical College, Kozhikode, Kerala, India

Phone number: 9809587773, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.