Abstract
Objectives: To study the presentation of seizures in neonate with special reference to clinical etiology and metabolic abnormalities. This study aims to find the etiology, metabolic abnormalities and time of onset in newborn presenting with neonatal seizures in NICU Rajah Muthaih Medical College.
Materials and Methods: This is prospective, observational hospital based study. This study include Hundred neonates, who had seizures within 28 days from birth admitted in Rajah Muthaih Medical College neonatal intensive care unit, were observed for etiological factor, clinical varient and metabolic abnormalities found in neonatal seizure.
Results: The result observed are subtle seizure forms the most common seizure, followed by clonic seizure [focal (25%), multifocal (12.5%). Tonic type of seizure in (7.5%) and myoclonic in (5%). Among metabolic abnormalities hypoglycaemia was found in (22%) and hypocalcaemia in (11%), followed by hyponatremia and hypokalemia Birth asphyxia is the most common cause of seizures, followed by infection and metabolic cause.
Keywords: Neonatal seizure, hypoglycaemia, clonic seizure, Birth asphyxia.
References
- Jensen FE. Developmental factors regulating susceptibility to perinatal brain injury and seizures. Curr Opin Pediatr 2006;18(6):628–33.
- Rahman S, et al. Inborn errors of metabolism causing epilepsy. Dev Med Child Neurol. 2013;55(1):23–36.
- Uria-Avellanal C, Marlow N, Rennie JM. Outcome following neonatal seizures. SeminFetal Neonatal Med.
- Rakhade SN, Jensen FE. Epileptogenesis in the immature brain: emerging mechanisms. Nat Rev Neurol. 2009; 5(7):380–91.
- Dzhala VI, Staley KJ. Excitatory actions of endogenously released GABA contribute to initiation of ictal epileptiform activity in the developing hippocampus. J 2003;23(5):1840–6.
- Temko A, et al. Robust neonatal EEG seizure detection through adaptive background modeling. Int J Neural Syst. 2013; 23(4):1350018.
- Temko A, et al. Inclusion of temporal priors for automated neonatal EEG classification. J Neural Eng. 2012; 9(4):046002.
- Slaughter LA, Patel AD, Slaughter JL. Pharmacological treatment of neonatal seizures: a systematic review. J Child Neurol. 2013;28(3):351–64
- Lynch NE, et al. The temporal evolution of electrographic seizure burden in neonatal hypoxic ischemic encephalopathy. 2012;53(3):549–57
- Glass HC, et al. Neonatal seizures: treatment practices among term and preterm infants. Pediatrv Neurol. 2012; 46(2):111–5
- Talos DM, et al. Antiepileptic effects of levetiracetam in a rodent neonatal seizure model. Pediatr Res. 2013; 73(1):24–30.
- Kilicdag H, et al. The effect of levetiracetam on neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury. Early Hum Dev. 2013; 89(5): 355–60.
- Sharpe CM, et al. A seven-day study of the pharmacokinetics of intravenous levetiracetam in neonates: marked changes in pharmacokinetics occur during the first week of life. Pediatr Res. 2012; 72(1):4.
- Lundqvist M, et al. Efficacy and safety of lidocaine for treatment of neonatal seizures. Acta Paediatr. 2013; 102(9): 863–7.3–9.
- Clark AM, et al. Intravenous topiramate: Comparison of pharmacokinetics and safety with the oral formulation in healthy volunteers. Epilepsia. 2013;54(6):1099–105.
Corresponding Author
Dr S. Saravanan
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DOI: https://dx.doi.org/10.18535/jmscr/v6i10.169
