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Category: Volume 06 Issue 10 October 2018
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Title: Estimation of Plasma Fibrinogen Levels in Acute Stroke Patients

Authors: Dr Perumalla Varun Kumar, Dr Gaddam Srinivas Reddy

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i10.129

Abstract

Fibrinogen is an acute phase protein, which is produced by Hepatocytes. Human fibrinogen is an independent predictor of coronary heart disease and stroke. Elevated fibrinogen levels are associated with a blood coagulation condition. It is therefore of interest to measure the plasma fibrinogen levels in patients with acute stroke and also to investigate whether these levels increase if the patient has additional risk factors like hypertension, diabetes, and smoking. About 30 patients of acute stroke patients admitted within 24 hours of development of symptoms at Kamineni Institute of Medical Sciences, Telangana were included in the study. Fasting plasma fibrinogen in mg/dl was estimated using Clauss method and compared with control group with same age, sex and risk factors. Out of the total 30 patients, mean plasma fibrinogen levels were significantly higher in stroke patients (455.84±12.36mg/dl) when compared to control patients (282.35±13.49mg/dl). In this 26 had ischemic stroke and 4 had hemorrhagic stroke. Fibrinogen levels were significantly higher in males, and it showed increasing levels as the age advances. Hypertension, Smoking, diabetes and obesity also influence levels of plasma fibrinogen.

Keywords: Ischemic stroke, Hemorrhagic stroke, Fibrinogen, Diabetes, Hypertension.

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Corresponding Author

Dr Gaddam Srinivas Reddy

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