Title: Role of Glucosamine Sulphate Supplements on Intra Ocular Pressure Given in Osteoarthritis Treatment– A Case Series
Authors: Dr N.Suhasini, Dr M.Harini, Dr T.Rajasekhar
DOI: https://dx.doi.org/10.18535/jmscr/v6i10.113
Abstract
Aim: To analyze role of Glucosamine sulphate supplements given for treatment of Osteoarthritis on intraocular pressure.
Materials & Methods: A case series of 100 patients who were diagnosed to have Osteoarthritis were selected and started on Glucosamine sulphate supplements in whom IOP was measured and analyzed for 1 year (From March 2017-March 2018) in GIMSR
Results: Out of 111 patients selected for study,11 patients were excluded as they were having high IOP, glaucomatous changes in fundus , corneal irregularities and postoperative cases
- Out of 100 patients 78 were females and 22 were males
- Most common age group being 40 to 60 years in both males and females
- IOP changes were more common in females than males
- IOP rise of 2mm Hg was identified in both eyes after a period of 1 year in considerable no of patients
Conclusions: Out of total number of 20,000 patients attended Orthopaedics department from March 2017 to March 2018 in GIMSR, 5000 patients complained of kneeproblem. Among them 100 patients were selected for the study. Patients with previous history of glaucoma, previous surgeries, fundus changes, not willing for regular follow up and corneal abnormalities were excluded from the study. Measurement of IOP was done in all 100 patients before starting of Glucosamine sulphate and patients were instructed to come for regular follow-ups 5 times at 3 months interval.
- In our study major proportion of patients were females constituting78% compared to males who were only 22%.
- Commonest age group effected both in males and females was 40-60 years.
- Normal range of 10 to 20 mm Hg IOP was seen in almost 90% of patients.
- After administration of Glucosamine for a period of 3 months not much IOP change is noticed
- After 6 months 34% of patients have shown 2 mm Hg increase in IOP in both eyes but were within normal range
- Thus Glucosamine sulphate can be used in Osteoarthritis with regular monitoring of IOP and considered to be relatively safe.
Keywords: Glaucoma, intra ocular pressure, Osteoarthritis.
References
- RK, Ketzler L, Rice RD, Johnson SM, Doss MS, Jaccoma EH. Oral glucosamine supplements as a possible ocular hypertensive agent. JAMA Ophthalmol 2013; 131:955-957. [PubMed]
- Binninger EA, Schachtschabel DO, Rohen JW. Exogenous glycosaminoglycans stimulate hyaluronic acid synthesis by cultured human trabecular-meshwork cells. Exp Eye Res 1987; 45: 169–177. [PubMed]
- Deal CL, Moskowitz RW. Nutraceuticals as therapeutic agents in osteoarthritis. The role of glucosamine, chondroitin sulfate and collagen hydrolysate. Rheum Dis Clin North Am 1999; 25: 379–395. [PubMed]
- Pavelka K, Gatterova J, Olejarova M, Machacek S, Giacovelli G, Rovati LC. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 2002; 162: 2113–2123. [PubMed].