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Category: Volume 06 Issue 10 October 2018
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Title: Correlation of Serum Zinc and Glycated Hemoglobin (HbA1C) of Newly Diagnosed Type 2 Diabetes Mellitus Patients in a Tertiary Hospital of Chidambaram

Authors: Dr K. Sunthari, Dr N. Chidambaram, Dr R. Umarani

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i10.93

Abstract

To analyse the FBS, PPBS, HbA1C and serum Zinc in patients with Type 2 DM. The study was carried out on 50 newly diagnosed patients of Type 2 DM and controls in the Department of Medicine, RMMCH, Annamalai University, Chidambaram. Analysis of FBS, PPBS, Serum Zinc, HbA1C, Serum Urea, Serum Creatinine were done by standard methods. FBS, PPBS values were statistically higher in diabetic group than control group. (P< 0.001) and the mean HbA1C % was also higher in cases (8.73 ±1.52 % & p=0.001). The average serum Zn level in cases was lower than controls (77.98 ± 11.02 vs 115.08 ± 23.91) and p<0.001 with correlation coefficient r =­0.689. Our study revealed a negative relationship between HbA1C% and serum Zinc in patients with type 2 DM.

Keywords: Chidambaram, serum Zn, HbA1C %, Type 2 DM.

References

  1. IDF Diabetes Atlas - The Economic Impacts of Diabetes. [http:// diabetes atlas. com/ content/economic-impacts-diabetes].
  2. Zimmer P, Alberti KG, Shaw J. Global and Societal Implication of the Diabetes Epidemic. Nature. 2001; 414:782–7. [PubMed]
  3. Chausmer AB. Zinc, insulin and diabetes. J Am Coll Nutr. 1998;17:109–115. [PubMed]
  4. Rai V, Iyer U, Mani I, Mani UV. Serum Biochemical changes in Insulin Dependent and Noninsulin Dependent Diabetes Mellitus and their role in the Development of Secondary Complications. Int Diabetes Dev Ctries. 1997;17:33–7.
  5. Tripathy S, Sumathi S, Bhupal Raj G. Minerals Nutritional Status of Type 2 Diabetic Subjects. Int J Diabetes Dev Ctries. 2004;24:27–8.
  6. Hyun-Mee Oh, Jin-Sook Yoon. Glycemic control of type 2 diabetic patients after short-term zinc supplementation. Nutrition Research and Practice. 2008;2:283–8. [PMC free article] [PubMed]
  7. Diabetes Control and Complications Trial Research Group. ‘The relationship of glycemic exposure (HbA) to the risk of development and progression of retinopathy in the diabetes control and complications trial’ Diabetes. 1995;44:968. [PubMed]
  8. Nathan DM, Singer DE, Hurxthal K, Goodson JD. The clinical information value of the glycosylated hemoglobin assay. N Engl J Med. 1984;310:341–6. [PubMed]
  9. American Diabetes Association: Standards of medical care in diabetes. Diabetes Care. 2010;33(Suppl 1):S13. [PMC free article] [PubMed]
  10. Akita Abe, Yiamashita S. Clin Chem. 1989;35(4):552–4. [PubMed]
  11. Tetsuo Makino. Clin Chem Acta. 1991;197:209–20.
  12. Trivelli LA, Ranney HM, Lai HT. Hemoglobin components in patients with diabetes mellitus. N Engl J Med. 1971;284:353–7. [PubMed]
  13. Bunn HF. Evaluation of glycosylated hemoglobin in diabetic patients. Diabetes. 1981;30:613–17. [PubMed]
  14. Trinder P. Glucose oxidase-peroxidase method. Ann Clin Biochem. 1964;6:24.
  15. Raabo E, Terkildsen TC. On the enzymatic determination of blood glucose. Scand J Clin Lab Invest. 1960;12:402–07. [PubMed]
  16. Berthelot MP. Berthelot's reaction mecha-nism. Report Chim Appl. 1859:2884.
  17. Fawcett JK, Scott JE. J Chim Pathol. 1960;13:156. [PMC free article] [PubMed]
  18. Bosnes RW, Taussy HH. On the colorimetric determination of creatinine by the Jaffe reaction. J Biol Chem. 1945;158:581–91.
  19. Toro G, Ackermann PG. Boston: Little Brown and Co; 1975. Practical Clinical Chemistry; p. 154.
  20. Kinlaw WB, Levine S, Morley J, Silvis S, McClain C. Abnormal Zn metabolism in type II diabetes mellitus. Am J Med. 1983; 75:273–7. [PubMed]
  21. Zalewski P, Millard S, Forbes I, Kapaniris O, Slavotinek S, Betts W, Ward A, et al. Video image analysis of labile Zn in viable pancreatic islet cells using specific fluorescent probe for Zn. J Histochem Cytochem. 1994; 42:877–84. [PubMed]
  22. Williams NR, Rajput-Williams J, West J, Nigdikar S, Foote J, Howard A. Plasma, granulocyte and mononuclear cell copper and zinc in patients with diabetes mellitus. Analyst. 1995; 120: 887–90. [PubMed]
  23. McNair P, Kiilerich S, Christiansen C, Christiansen M, Madsbad S, Transbol I. Hyperzincuria in insulin treated diabetes mellitus-its relation to glucose homeostasis and insulin administration. Clinica Chi-mica Acta. 1981; 112:343–8. [PubMed]
  24. Garg V, Gupta R, Goal R. Hypozincemia in diabetes mellitus. J Assoc Physicians India. 1994; 42: 720–1. [PubMed]
  25. The Diabetes Control and Complications Trial Research Group. N Engl J Med. 1993;329:977–86. [PubMed]
  26. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ. 1998;317:703. [PMC free article] [PubMed]
  27. Khaw KT. Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European Prospective Investigation of Cancer and nutrition (EPIC-Norfolk) BMJ. 2001;322:15–18. [PMC free article] [PubMed]
  28. Verma Effect of Increasing Duration of Diabetes Mellitus Type 2 on Glycated Hemoglobin AndInsulin Sensitivity, Indian. J Clin Biochem. 2006;21:142–6. [PMC free article] [PubMed]
  29. Refaat A, Al-Maroof, Shatha S, Al-Sharbatti Serum zinc levels in diabetic patients and effect of zinc supplementation on glycemic control of type 2 diabetics. Saudi Med J. 2006;27:344–50. [PubMed]
  30. Marchesini G, Bugianesi E, Ronchi M, Flamia R, Thomaseth K, Pacini G. Zinc supplementation improves glucose disposal in patients with cirrhosis. Metabolism. 1998;47:792–8. `[PubMed]

Corresponding Author

Dr K. Sunthari

Post Graduate, Department of General Medicine, Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalai Nagar – 608002