Title: Benefits of Transdermal Nitroglycerine Patch in the Prevention of Preterm Labour
Authors: Prof. Dr Latha.K, Dr Jayashree.V, Dr Kousalya Devi.A
DOI: https://dx.doi.org/10.18535/jmscr/v6i10.90
Abstract
Preterm birth is delivery before 37 completed weeks. Majority of complications occur before 33 weeks. Preterm labour remains as enigma in obstetrics even today. The need of today is to select the best to colytic agent with benefit. The study aims to found the benefits of transdermal nitroglycerine patch in prevention of preterm labour.
Method: study conducted in department of obstetrics and gynaecology, Rajah Muthiah Medical College and Hospital, Chidambaram. A prospective randomized study of 80 women of preterm labour was enrolled after informed consent from them. Patients were given transdermal NTG patch as tocolytic agent. According to study protocol.
Result: 1) Successful tocolytic was observed in majority of women (66.2%). 2) Side effect was also less in NTG.
Conclusion: This randomized prospective study supports to use of NTG patch in case of safety, effectiveness, cost effective and it is non invasive method of tocolysis.
Keywords: Dermal nitroglycerine patch tocolysis (NTG 10).
References
- Martin DH, et al., double blinded placebo controlled treatment trial of Chlamydia trachomatis endo cervical infection in pregnant woman. Infect dis obst gynec, 1997; 5:10.
- Klein Jo, Braun P and Lee YH et al., Birth weight and genital mycoplasma in pregnancy. N Eng J Med., 1971; 284:167-171.
- Benito CW and Blusewicz TA. The relationship of ureaplasma urealyticum cervical colonization and preterm delivery in high risk pregnancies obstet gynecol.
- Edwards LE, Barrada MI, Hamann AA and Hakanson EV: Gonorrhea in pregnancy, AJOG, 1978; 132:637-641.
- Fuch AR-oxytocin receptors in the human uterus during pregnancy and parturition, AJOG, 1984; 150:734.
- Arias F. Pharmacology of oxytocin & Prostaglandins, Clinical obstet gynecol, 2000; 43:455-68.
- Cox SM, King MR, Casey ML and Mac Donald PC: Interleukin 1, -1and -6 and Prostaglandins in vaginal and cervical fluids of pregnant women before and during labour. J Clin Endocrinol metab, 1993; 77:805-815.
- NIH consensus statement: Effect of corticosteroids for fetal maturation and perinatal outcomes, Vol.12, No.2, Bethesda National Institute of Health, 1994.
- Tocolytic drugs for women in preterm labor RCOG clinical Guidelines no.1 (B), October, 2002.
- Johnson JWC, Austin KL and Jones GS, et al. Efficacy of 17 Alpha Hydroxyprogesterone caproate in the prevention of premature labor. N Engl J Med, 1975; 293:675.
- Steer CM, Petric RH. A comparison of Magnesium sulfate and alcohol for the prevention of premature labor, AJOG, 1977; 129:1.
- Canadian Preterm Labor Investigations group treatment of preterm labor with beta adrenergic agonist ritodrine, N Engl J Med, 1992; 327:308.
- Weristorm K, Weiner CP and Merrill D et al. A placebo controlled randomized trial of the terbutaline pump for prevention of preterm delivery, Am J Perinatol, 1997; 14:87.
- Elliott JP. Magnesium sulfate as a tocolytic agent, AJOG, 1983; 147: 277.
- Muench MV, Baschat AA and Kopelman J, et al. Indomethacin therapy initiated before 24 weeks of gestation for the prevention of preterm birth obstet Gynecol, 2003; 101:655.