Abstract
Background: The high incidence of duodenal ulcer and perforated duodenal ulcers in this part of the country prompted us to test the hypothesis that, duodenal ulcer perforations may be associated with Herpes simplex virus infection. There is apparent absence of risk factors in DU perforation. Also it is associated with very short duration of pre-perforation dyspepsia in a significant number of perforated duodenal ulcers. It appeared that there is a high possibility that atleast a subset of these perforations could be due to Herpes simplex virus I or 2 infections.
Aim: To assess the role of Herpes Simplex Virus type I and II in duodenal- ulcer perforation.
Materials and Methods: This was a case-control study with three groups of 65 patients. Controls were formed by patients with no symptoms of upper gastrointestinal diseases who were admitted for non-gastrointestinal disorders. Case group again subdivided to a Second group of patients with acute duodenal ulcer perforation and a third group with chronic duodenal ulcer perforation.
Results: Significant statistical difference in seropositivity for HSV I & II was found in patients with both acute and chronic duodenal perforation vs controls. (P<0.05) For both HSV I and HSV II, there was a significant association between the seropositivity rates and size of acute DU perforation. P <0.05. Statistically significant difference in seropositivity to both HSV I and HSV II was seen in NSAID users. However, in the case of alcoholics and non- alcoholics, significant difference was noticed for seropositivity to HSV I only. In the case of smokers and non-smokers, there was no significant difference in the seropositivity to HSV I and II in all cases. There was a significant trend to higher seropositivity in patients with shorter pre-perforation duration and dyspepsia, for both HSV I and HSV II. There is a trend towards higher HSV titres in perforated DU compared to controls, which is statistically significant.
Keywords: herpes simplex virus (HSV), duodenal ulcer (DU).
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Corresponding Author
Dr Premlal A.P
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DOI: https://dx.doi.org/10.18535/jmscr/v6i10.76
