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Category: Volume 06 Issue 10 October 2018
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Title: H. Pylori Infection Status in Cases of Acid Peptic Disease Patients in Rural Population of Malwa Region of Madhya Pradesh

Authors: Dr Manuj Kumar Sarkar, Dr Ravija Prasad, Dr Rishu Bansal

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i10.21

Abstract

Introduction: Peptic ulcer disease (PUD) is very common problem encountered by physicians in day-to-day practice. Prevalence of this disease varies from country to country and Previous concept regarding PUD was that “no acid, no ulcer”. Now, it is certain that H. pylori is the main agent causing peptic ulcer.H. pylori is found in 95% of patients with duodenal ulcers and 70% of cases with gastric ulcers. H. pylori infection is chronic and once acquired remains life long, unless eradicated by antibiotics given for some other conditions.

Methods and Materials: This study was conducted on 100 acid PUD patients at Internal Medicine Department of Index Medical College Hospital and Research Centre, Indore from October 2017 to April 2018.Patients who were suffering from symptoms related to PUD who gave consent for upper gastrointestinal endoscopy, those patients were selected for this study and the H. pylori infection was detacted by rapid urease test (RUT) kit test.

Results: Among the 100 patients of PUD who were studied in this study, 75 patients had RUT positive result and 25 patients had RUT negative result. It was also observed that amongst the RUT positive patients, those who had strongly positive RUT status, they had more severe form of peptic ulcer disease, whereas weakly positive RUT patients had moderately severe form of the disease, and those who had negative RUT report, they had very minor form of the disease.

Conclusion: High prevalence of H. pylori infection is found in patients suffering from PUD in rural India hence its treatment can help in preventing significant morbidity as well as recurrence in these patients. Patients with various complaints, where UGI endoscopy is done, they should routinely have their H. pylori status checked, regardless of indication.

Keywords: Peptic ulcer disease, H. pylori, Upper gastrointestinal endoscopy, Rapid Urease Test.

References

  1. YK Joshi; Helicobacter Pylori Infection : Current Status. A review article. Journal of Indian Academy of Clinical Medicine, vol.5 no.2, page: 148-155.
  2. Malfertheiner P, Megraud F, O’Morain CA, et al.; European HelicobacterStudy Group. Management of Helicobacter pylori infection—the Maastricht IV/ Florence Consensus Report. Gut. 2012;61(5):646-664.
  3. Ford AC, Delaney BC, Forman D, Moayyedi P. Eradication therapy for peptic ulcer disease in Helicobacter pylori positive patients. Cochrane Database Syst Rev. 2006;19(2):CD003840.
  4. Papatheodoridis GV, Sougioultzis S, Archimandritis AJ. Effects of Helicobacter pylori and nonsteroidal anti-inflammatory drugs on pepticulcer disease. Clin Gastroenterol Hepatol. 2006;4(2):130-142.
  5. Salama NR, Hartung ML, Müller A. Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. Nat Rev Microbiol. 2013;11(6):385-399.
  6. Federico A, Gravina AG, Miranda A, Loguercio C, Romano M. Eradication of Helicobacter pylori infection: which regimen first? World J Gastroenterol. 2014;20(3):665-672.
  7. Chey WD, Wong BC. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol. 2007.102(8):1808-1825.
  8. John Del Valle. Peptic Ulcer Disease and Related Disorders.348. In: Dennis L. Kasper, Stephen L. Hauser, J. Larry Jameson, Anthony s. Fauci, Dan L. Longo, Joseph Loscalzo. Harrison’s Principles of Internal Medicine, 19E. United States Of America: McGraw-Hill Education, 2015, Vol.2,PP(1914-1932)
  9. Dewan B, Shah D (2013) A Study to Evaluate the Symptomatic Efficacy and Safety of LafaxidTM (Lafutidine 10 mg) in Patients with Acid Peptic Disorders in India. Br J Med Med Res 3: 821-831.
  10. Miller TA (1988) Emergencies in acid-peptic disease, Gastroenterology Clinics of North America 17: 303-315.
  11. Smallwood R (1995) The management of acid peptic disease, Australian Prescriber 18; 97-99.
  12. Wyatt JI, Rathbone BJ, Dixon MF, Heatley RV. Campylobacter pyloridis and acid induced gastric metaplasia in the pathogenesis of duodenitis. J CilnPathol. 1987;40:841. 
  13. Goodwin CS. Duodenal ulcer, Campylobacter pylori and the “leaking roof” concept. Lancet. 1988;ii:1467. 
  14. Graham DY. Campylobacter pylori and peptic ulcer disease. Gastroenterology. 1989;96:615.

Corresponding Author

Dr Manuj Kumar Sarkar

Associate Professor, Department of Medicine, Amaltas Institute of Medical Sciences, Devas, MP, India

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