Title: HLA-B27 and Ankylosing Spondylitis - A One Year Study
Authors: Prof. Dr C.V. Kulkarni, Dr Sachin Sharma, Dr Sweta Tripathi
DOI: https://dx.doi.org/10.18535/jmscr/v6i10.03
Abstract
Background: HLA-B27 also known as Human Leukocyte Antigen is a class 1 antigen of the major histocompatibility complex and is strongly associated with Ankylosing spondylitis (AS). The purpose of the present study is to investigate the distribution of HLA-B27 in patients with AS of different groups in Indore.
Design and Setting: Study design was cross-sectional and the setting was in the rheumatology clinics of Maharaja Yashwant Rao Hospital in Indore where most of Ankylosing spondylitis patients were followed up.
Methods and Materials: Patients with diagnosis of AS who met the New York modified criteria for AS was tested for HLA-B27. Approximately 80 patients were tested for HLA-B27 with the help of flowcytometer in the department of pathology, MYH hospital, Indore.
Results: Of all the individuals, 66 were positive (82.5%) for HLA-B27.
Conclusion: HLA-B27 in our small group of patients is present in 82.5%, suggests that HLA-B27 is important factor in the pathogenesis of Ankylosing spondylitis.
Keywords: Ankylosing spondylitis (AS), and HLA-B27, Male (M), Female (F).
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