Details
Category: Volume 06 Issue 09 September 2018
Hits: 1148

Title: Evaluation of Feto-Maternal Outcome in Pregnancy Complicated by Thrombocytopenia

Authors: Shazia Jeelani Samoon (DGO, DNB), Imtiyaz Ganaie (MD), Tazeen Jeelani Samoon (MD), Rifat Gull (BSc, MA)

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i9.168

Abstract

Objective: Evaluation of feto-maternal outcome in pregnancy complicated by thrombocytopenia.

Methods: The study was conducted in the department of obstetrics and gynecology, SKIMS Medical College and Sher-e-kashmir institute of medical sciences, Kashmir from June 2017 to August 2018. Total of 200 pregnant women were studied including 100 women with pregnancy thrombocytopenia as cases and 100 pregnant women without thrombocytopenia as control among the women admitted in wards and labour room.

Results: the mean period of gestation was significantly less among women with thrombocytopenia. The mean birth weight, Apgar score at 1 minute and Apgar score at 5 minutes was less in cases as compared to control. The mean platelet count among cases of thrombocytopenia has shown significant rise between 48 hours and 6 weeks after delivery.

Conclusion: Preterm labour and low birth weight is more common in pregnancy complicated by thrombocytopenia. Maternal complications are more in cases than in controls; therefore careful surveillance is required for early detection and management of complications in pregnancy complicated by thrombocytopenia.

Keywords: Pregnancy, thrombocytopenia and preterm labour.

References

  1. Kam PC, Thompson SA, Liew AC. Thrombocytopenia in the parturient. Anaesthesia 2004; 59: 255-264.
  2. James N, George MD. Thrombocytopenia in   January 14, 1998.
  3. McCrae KR, Bussel JB, Mannucci PM, Remuzzi G, Cines DB. Platelets: an update on diagnosis and management of thrombocytopenic disorders. Hematology Am Soc Hematol Educ. Program 2001: 282–305.
  4. McCrae KR, Samuels P, Schreiber AD. Pregnancy-associated Thrombocytopenia; pathogenesis and management. Blood 1992;80: 2697–2714.
  5. McCrae KR, Cines DB. Thrombotic microangiopathy during pregnancy. Sem Hematol 1997; 34: 148–158.
  6. Shehata N, Burrows RF, Kelton JG. Gestational thrombocytopenia. Clin Obstet Gynecol 1999; 42: 327–334.
  7. Burrows RF, Kelton JG. Thrombocy-topenia at delivery: a prospective survey of 6,715 deliveries. Am J Obstet Gynecol 1990; 162:731– 4.
  8. Michal Parnas, Eyal Sheiner, Ilana Shoham-Vardi , Eliezer Burstein,Tikva Yermiahu, Itai Levi et al. Moderate to severe thrombocytopenia during pregnancy. European Journal of Obstetrics & Gynecology and Reproductive Biology xxx (2006) xxx–xxx.
  9. McMinn JR, George JN. Evaluation of women with clinically suspected thrombotic thrombocytopenic purpura, hemolytic uremic syndrome during pregnancy. J Clin Apher. 2001; 16(4):202.
  10. Grzyb A,Rytlewski K, Domanska A, Tomaszczyk J, Basta A. Pregnancy complicated with thrombocytopenia. Ginekol Pol. 2006 Sep; 77(9):712-9.
  11. Bhat YR, Cherian CS. Neonatal thrombocytopenia associated with maternal pregnancy induced hypertension. Indian J Pediatr. 2008 Jun; 75(6):571-3
  12. Lain KY, Roberts JM. Contemporary concepts of the pathogenesis and management of preeclampsia. J Am Med Assoc 2002; 287:3183–6.
  13. Marco Ruggeri, Corrado Schiavotto, Giancarlo Castmann, Alberto Tosetto, Francesco Rodegiero. Gestational thrombocytopenia. Haematologica 1997; 82:341-342.
  14. Nisha S, Amita D, Uma S, Tripathi AK, Pushplata S. Prevalence and characterization of thrombocytopenia in pregnancy in Indian women. Indian J Hematol Blood Transfus. 2012 Jun; 28(2):77-81.
  15. Hellgren M. Hemostasis during normal pregnancy and puerperium. Semin Thromb Hemost. 2003; 29(2):125.

Corresponding Author

Imtiyaz Ganaie (MD)

Department of Gynecology and Obstetrics, Skims Medical College and Sher-I-Kashmir Institute of Medical Sciences, Kashmir, India