Title: Bilateral Gonadoblastoma with Extensive Calcification in 46 XX Karyotype Female- A Rare Case Report
Authors: Dr. Sushma Bharti MD, Dr. Shantilal M. Sisodia MD, Dr. Zeba Ali MD
DOI: https://dx.doi.org/10.18535/jmscr/v6i9.164
Abstract
Gonadoblastomas are rare tumors frequently appearing in the dysgenetic gonads with Y chromosome anomaly. We reported a case of gonadoblastoma in young female of age 16 years, admitted to our hospital for evaluation of early onset secondary amenorrhea since six month. Pubertal development was Tanner stage 3 and had normal 46XX karyotype. MRI Pelvis was suggestive of ovarian endometriomas. She underwent bilateral prophylactic gonadectomy. Pathological assessment found streak ovary with gonadoblastoma and foci of dysgerminoma component with extensive areas of calcification. The prophylactic gonadectomy is needed if patient carry Y chromosome or malignant components like dysgerminoma.
Keywords: Gonadoblastoma, dysgerminoma, calcification, karyotype
References
- Kanagal DV, Prasad K, Rajesh A, Kumar RG, Cherian S, Shetty H, et al. Ovarian gonadoblastoma with dysgerminoma in a young girl with 46, XX karyotype: A case report. J Clin Diagn Res 2013;7:2021‑2.
- Yi-Che Changchiena, Iren Haltrichb, TamasMicsika et al.Gonadoblastoma: Case report of two young patients with isochromosome 12p found in the dysgerminoma overgrowth component in one case.Pathology – Research and Practice 2012;628– 32.
- Ozge Yuce, Esra Doğer, Nurullah Celik et al. Gonadoblastoma with Dysgerminoma in a Phenotypically Turner-Like Girl with 45,X/46,XY Karyotype .J Clin Res Pediatr Endocrinol 2015;7(4):336-9.
- Scully RE.Gonadoblastoma – a review of 74 cases. Cancer 1970; 25: 1340-56.
- Gelincik I, Ozen S, Bayram I. Left ovarian gonadoblastoma with yolk sac tumor in a young woman. Indian J PatholMicrobiol 2010;53:345-6.
- Kulkarni MM, Khandeparkar SGS, Joshi AR, Bhayekar PV.Unilateral gonadoblastoma with dysgerminoma in normal fertile woman having a child: Extremely rare occurrence with characteristic immunohistomorphology. Indian Journal of Pathology and microbiology 2016;59(4).
- Esin S, Baser E, Kucukozkan T, Magden HA.Ovarian gonadoblastoma with dysgerminoma in a 15‑year‑old girl with 46, XX karyotype: Case report and review of the literature. Arch Gynecol Obstet 2012;285:447‑51.
- Yilmaz B, Gungor T, Bayramoglu H, Soysal S, Mollamahmutoglu L. Bilateral ovarian gonadoblastoma with coexisting dysger-minoma in a girl with 46, XX karyotype. J Obstet Gynaecol Res 2010; 36(3):697-700.
- Tumours of the breast and female genital organs, IARC Press, Lyon, 2003.