Title: A Cross-sectional Study of Profile Serum Lipid levels in off-springs of Diabetic patients in a Tertiary Care Hospital in Central India
Authors: Rohit Manyal, Swati Agarwal
DOI: https://dx.doi.org/10.18535/jmscr/v6i9.150
Abstract
Aims & Objective: To compare various serum lipid parameteres in young healthy off-spring of diabetics (single or both parents) with offspring of non-diabetic parents.
Material and Methods: A cross sectional study with 120 subjects included ,60 normal healthy off-springs of diabetic parents (single parent diabetic 38 & both parent Diabetic 22) and 60 normal healthy off-springs of non-diabetic parents between age group of 18 to 30 years. All inclusion and exclusion criteria were applied after which subjects were enrolled and also informed written consent were taken. Serum lipid cholesterol level assay was done by Modified Roeschlaus’s method (Dynamic extended stability CHOD-POD method) by Fully Automatic Analyzer.
Results: The mean value of Serum HDL was lower in off-springs of both diabetic parents than offspring of non-diabetic parent and the difference was statistical significant (p=0.005**). We found Statistical significant difference in mean value of Serum HDL between offspring of single diabetic parent and offspring of non-diabetic parent (p= 0.042*) and mean value of Serum HDL was lower in offspring of both diabetic parents than offspring of single diabetic parent but the difference was not statistical significant (p=0.522).
Conclusion: Lipid profiles of off-springs were related to diabetic parent’s history. When both parents are diabetic their offspring should always be kept in follow-up as they have high chances of developing hyperglycemia in future.
Keywords: Lipid profile, High Density lipoprotein, Cholesterol.
References
- Diagnosis and Classification of Diabetes Mellitus, DIABETES CARE, VOLUME 31, SUPPLE MENT 1, JANUARY 2008.
- Hariri S, Yoon PW, Qureshi N, Valdez R, Scheuner MT, Khoury MJ. Family history of type 2 diabetes: A population-based screening tool for prevention? Genet Med. 2006;8:102–8.[PubMed]
- Sande MV, Walraven GL, Milligan PM, Banya WS, Caesay S, Nyan O, et al. Family history: An opportunity for early interventions and improved control of hypertension, obesity and diabetes. Bull World Health Organ. 2001;79:321–8
- Ohlson LO, Larsson B, Svardsudd K, Welin L, Eriksson H, Wilhelmsen L, et al. The influence of body fat distribution on the incidence of diabetes mellitus. 13.5 years of follow-up in the participants in the study of men born in 1913. Diabetes. 1985; 34:1055–8.
- Helmrich SP, Ragland DR, Leung RW, Paffenbarger RS., Jr Physical activity and reduced occurrence of non-insulin dependent diabetes mellitus. N Engl J Med. 1991; 325:147–52.
- Barnett AH, Eff C, Leslie RD, Pyke DA. Diabetes in identical twins.A study of 200 pairs. Diabetologia. 1981;20:87–93
- Pierce M, Keen H, Bradley C. Risk of diabetes in offspring of parents with non-insulin dependent diabetes. Diabet Med. 1995; 12:6–13.
- Fukomoto S, Martin TJ. Bone as an endocrine organ. Trends Endocrinol metab 2009; 20:230-236
- Benigno Linares Segovia, Maximiliano Guti´errez Tinoco, Angeles Izquierdo Arrizon, Juan Manuel Gu´ızar Mendoza and Norma Amador Licona. Long Term Consequences for Offspring of Paternal Diabetes and Metabolic Syndrome. Hindawi Publishing Corporation Experimental Diabetes Research Volume 2012, Article ID 684562, 5 pages
- Adeela Shahid, Khalid P. Lone, Sadia Saeed, Muhammad Arslan. Male offspring of both diabetic parents have higher insulin resistance and serum leptin levels compared to those with one diabetic parent. HORMONES 2008, 7(4):313-319
- Kumiko Hirata, Amudha Kadirvelu, Marco Di Tullio, Shunichi Homma, Anna Maria Choy. Coronary Vasomotor function is abnormal in first degree relatives of patients with type 2 Diabetes. Diabetes Care, Volume 30, number 1, January 2007: 150-153.
- Gerich JE (1998) the genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity. Endocr Rev 19: 491-503
- Steinberger J, Daniels SR; Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council of Cardiovascular Disease in the Young); American Heart Association Diabetes Committee(Council on Nutrition, Physical Activity, et al. (2003) Obesity, insulin resistance, diabetes, and cardiovascular risk in children: an American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism).Circulation 107: 1448-1453
- Meraj Rahim, Mariam Rahim, Masood Anwar Qureshi, ShaheenSharafat, Zaman Shaikh et al. LIPID Profile and Growth Indicators among Offspring’s of Diabetic Parents in Karachi J Diabetes Metab. 2014; 5:10