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Category: Volume 06 Issue 09 September 2018
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Title: Evaluation of Hematological profile in Chronic Kidney Disease patients in a Tertiary Care Center, Kanchipuram: A Cross Sectional Study

Authors: Saumya, V. Eswari

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i9.118

Abstract

Introduction: Anemia is a very common complication of chronic kidney disease (CKD) and is associated with a poor cardiac health, cognitive function and an overall quality of life. We aimed to assess the various hematological changes in patients with chronic kidney disease and to assess the correlation between hemoglobin and serum creatinine.

Methodology: The study was conducted for a period of one year during which 60 patients with a diagnosis of CKD, and having a serum creatinine value higher than 1.5 mg/dl were included in our study using a predesigned semi-structured questionnaire, we recorded clinical and laboratory related information of the patients. The patients were classified into stages of CKD using eGFR (Estimated Glomerular Filtration Rate). Spearman’s correlation coefficient was calculated to look for correlation between hemoglobin and serum creatinine.

Results: Majority of the patients (n=34) had serum creatinine between 5.1 and 10 mg/dl and half of all patients had hemoglobin level between 7.1 and 10 mg/dl. Iron Overload was seen in 42 patients, and majority of the patients were in CKD stage 4 and 5. Decreased mean serum iron, transferrin and total iron binding capacity was seen in remaining patients.

Conclusion: Prompt identification and correction of anemia in patients with CKD is recommended.  Further detailed studies are required to support the results of our study.

Keywords: Chronic kidney disease,Anemia,Creatinine.

References

  1. Bright R. Cases and observations illustrative of renal disease accompanied with the secretion of albuminous urine. Guy's HospRep.. 1836;1:336.
  2. Decreased GF.Definition and classification of CKD.Kidney International. 2013;3:19-62.
  3. Levey AS, Eckardt KU, Tsukamoto Y, Levin A, Coresh J, Rossert J, Zeeuw DD, Hostetter TH, Lameire N, Eknoyan G. Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney international. 2005;67(6):2089-100.
  4. Hsu CY. Epidemiology of anemia associated with chronic renal insufficiency. Current opinion in nephrology and hypertension. 2002 May 1;11(3):337-41.
  5. NKF-K/DOQI Clinical Practice Guidelines for Anemia of Chronic Kidney Disease. Am J Kidney Dis 2006;47(Suppl 4):S1
  6. Grützmacher P, Scheuermann E, Löw I, Bergmann M, Rauber K, Baum R, Heuser J, Schoeppe W. Correction of renal anaemia by recombinant human erythropoietin: Effects on myocardial function. InTreatment of Renal Anemia with Recombinant Human Erythropoietin 1988 (Vol. 66, pp. 176-184).Karger Publishers.
  7. Obrador GT, Roberts T, Peter WL, Frazier E, Pereira BJ, Collins AJ.Trends in anemia at initiation of dialysis in the United States. Kidney international. 2001;60 (5):1875-84.
  8. Przybylowski P, Wasilewski G, Golabek K, Bachorzewska-Gajewska H, Dobrzycki S, Koc-Zorawska E, Malyszko J. Absolute and Functional Iron Deficiency Is a Common Finding in Patients With Heart Failure and After Heart Transplantation. Transplantation Proceedings 2016;1 (48):173-176.
  9. Anker SD, Colet JC, Filippatos G, et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med 2009;361:2436e48.
  10. Trottier BJ, Burns LJ, DeFor TE, Cooley S, Majhail NS. Association of iron overload with allogeneic hematopoietic cell transplantation outcomes: a prospective cohort study using R2-MRI–measured liver iron content. Blood. 2013;122(9):1678-84.
  11. Talwar VK, Gupta HL, Shashinarayan. Clinicohaematological profile in chronic renal failure. JAPI 2002; 50: 228-33.
  12. Ajay k. Singh, Youssef MK Farag, Bharati V Mittal et al. Epidemiology and risk factors of chronic kidney disease in India- results from the SEEK (Screening and early Evaluation of Kidney Disease) study, BMC. Nephrology 2013; 14: 114.
  13. Bhattacharjee et al. A study on haematological profile in patients of chronic renal fgailure with special reference to serum iron profile. J of Evidence Based Med & Hlthcare /Vol.2/Issue46/Nov,09,2015.Page 8212 -8219.
  14. Agarwal SK, Dash SC, Irshad M, Raju S, Singh R, Pandey RM. Prevalence of chronic kidney failure in adults in Delhi. India Nephrol Dial Transplant 2005; 20(8): 1638-42.
  15. Kovesdy, Csaba P. Hyponatremia, hypernatremia and mortality in patients with chronic kidney disease with and without congestive heart failure- Clinical Perspective. Circulation 2013; 125. 5:677-684.
  16. Guenter Weiss, M.D., Lawrence T. Goonough, M.D. Anaemia of chronic disease, N ENGL J MED 352;10 March 2005 1011-2023.

Corresponding Author

V Eswari

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