Title: The effects of microcytic hypochromic anemia on HBA1C in non-diabetics
Authors: Dr Jeyhan Dhabhar, Dr Aakash Barad, Dr Jaishree Ghanekar
DOI: https://dx.doi.org/10.18535/jmscr/v6i9.98
Abstract
Background: Hemoglobin A1c reflects patient’s glycemic status over previous 3 months. Iron deficiency anemia elevates hbA1c concentration independent of glycemia. This study aim to analyze effect of microcytic hypochromic anemia on HB1C in non-diabetic.
Inclusion Criteria
Males and females,18 – 60 year age group, Microcytic and hypochromic anemic patients, Non diabetics.
Exclusion Criteria
Below 18 years and above 60 years, Known diabetics, Anemia other than microcytic hypochromic, Patients with heamoglobinpathies and haemolytic anemia, History of acute or chronic blood loss, Acute renal failure & chronic renal failure patients, Pregnant females, History of chronic alcoholism.
Aims & Objectives: The study aimed to find the co relation between microcytic hypochromic anemia and glycosylated hemoglobin and to exercise caution while using HbA1C levels to diagnose diabetes in patients who have microcytic hypochromic anemia.
Material & Methods: The study was conducted at MGM Hospital Kamothe over a period of two years with 50 patients and 50 control group which include all non-anemic, non-diabetic individuals. HbA1c was compared in the anaemic group vs. non-anaemic control group
Results: The study established that HbA1c was significantly raised in anemic individuals, hence it is imperative to watch for anemia or to avoid using HbA1c altogether as a diagnostic or prognostic test for diabetes in anemic patients. The study establishes HbA1c is raised in individuals with microcytic hypochromic anemia. In anemic individuals novels markers like glycated albumin and frcutosamine may be used as an alternative to HbA1c.
Keywords: Microcytic Hypochromic anemia, glycosylated hemoglobin.
References
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- Kim, C., Bullard K., Herman, W., Beckles, G. (2010). Association between Iron Deficiency and A1C Levels among Adults without Diabetes in the National Health and Nutrition Examination Survey, 1999–2006. Diabetes Care. 2010 April; 33(4): 780–785.
- Sinha, N., Mishra, T., Singh, T., Gupta, N. (2012). Effect of Iron Deficiency Anemia on Haemoglobin A1C Level. Ann Lab Med. 2012 January; 32(1): 17–22.
- The HbA1c ranged from 5.30% to 6.4% with a mean of 5.938% in the case group. In the control group it ranged from 4.0% to 5.2% with a mean of 4.696%.On applying statistical tests the p-value <0.05 indicated that HbA1c was significantly raised in the case study group.
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