Title: Comparative Histopathological Effects of Metformin and Glibenclamide on Liver in Alloxan Induced Diabetic Albino Rats
Authors: Nuzhat Bashir, Aijaz Ahmad Patloo, Nadia Bashir
DOI: https://dx.doi.org/10.18535/jmscr/v6i9.34
Abstract
Introduction: Diabetes mellitus is a systemic metabolic disorder characterised by elevated blood glucose levels due to absolute or relative deficiency of insulin secretion from pancreatic β-cells. Diabetes is responsible for causing impairment in liver functions. Oral hypoglycemic drugs like metformin and glibenclamide improved functions of liver. Hence in this study we evaluated the comparative histopathological effect of metformin and glibenclamide on liver in Alloxan induced diabetic rats.
Material and Methods: The present study was conducted on 24 experimental animals which were divided into four groups of with 6 rats in each group and were treated accordingly Group 1:Healthy control (HC) rats, Group 2: Diabetic control (DC) rats, Group 3: Diabetes mellitus (DM) + Metformin (M) rats, Group 4: Diabetes mellitus (DM) + Glibenclamide (G) rats. After 28 days of treatment rats were sacrificed and blood glucose and body weight was determined along with histopathological study of liver
Result: The results showed that both Metformin and Glibenclamide reversed Alloxan induced diabetic histopathological changes in liver in Albino rats
Conclusion: The present Results demonstrate that normoglycemia with metformin and glibenclamide ameliorates diabetic induced histopathological lesions in liver
Keywords: Diabetes, Histopathology, Liver, Metformin, Glibenclamide.
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