Title: Influence of NK Cells during Epithelial to Mesenchymal Transition in Oral cancer
Authors: Priyashi Rao, Birva Raiya, Hemangini Vora
DOI: https://dx.doi.org/10.18535/jmscr/v6i7.161
Abstract
Oral carcinogenesis is a major health problem in the world. Over 90% of all Oral Cancer is classified as Oral Squamous Cell Carcinoma with loco regional relapse and cervical lymph node metastasis.Considering epithelial malignancies, the role of immune system in governing Epithelial to Mesenchymal Transition (EMT) has not been much investigated in oral cancer. The present investigation suggests a possible role of NK cells during EMT and its correlation to invasive properties of tumour. Athough a direct correlation couldn’t be established but the influence of NK cells on EMT could be seen which open up new horizon for immunotherapeutic strategies in the coming years.
Keywords: NK cells, invasion, Oral squamous cell carcinoma (OSCC), EMT, E-cadherin, Vimentin.
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