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Category: Volume 06 Issue 07 July 2018
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Title: Morphological Typing of Extranodal Lymphoma with Immunohistochemical Study

Authors: Dr K. S. Dhumure, Dr R. D. Hanmante, Dr S. W. Chopade, Dr R. S. Bindu

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i7.160

Abstract

Background: Lymphomas are neoplasms of the lymphoid tissue. It can affect the lymph nodes as well as extra-nodal tissue. A substantial percentage of non-Hodgkin's lymphomas arises from tissue other than lymph nodes. These are referred as primary extranodal lymphomas. The diagnosis of extranodal lymphoma requires clinico-pathological consideration and immunohistochemistry study. The present study includes the morphological typing of the Extranodal lymphoma with the help of Immunohistochemistry markers.

Methodology: This was the prospective study carried out in the pathology department at a tertiary care teaching hospital over a period of two years. Patients clinically suspected or diagnosed as extranodal lymphoma and those detected by histopathology were included in study. The results were confirmed with the help of Immunohistochemistry study.

Results: Total 35 cases of extranodal lymphoma were studied. The study population ranges from age group 06 to 76 years with mean age 46.7 years with M:F ratio 2.88:1. Gastrointestinal tract (60%) was the predominant site of primary extranodal lymphoma followed by Oral cavity (14.29%), Parotid (8.56%), Testis (5.71%) and 2.86% each of Ovary, Nose, Breast and Chest.

Histopathologically, all cases were of Non-Hodgkin’s lymphoma type. DLBCL was the commonest variant of extranodal lymphoma found during the study.

Conclusion: Morphology forms the basis of diagnosis of extranodal Lymphoma. WHO classification mandates the use of immunohistochemistry. IHC has diagnostic as well as therapeutic benefits.

Keywords: DLBCL, Extra-nodal, IHC, Lymphoma, NHL etc.

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Corresponding Author

Dr Rajharsh Dattatrey Hanmante

Associate Professor, Department of Pathology, Govt. Medical College Akola, Maharashtra.444001, India

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