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Category: Volume 06 Issue 07 July 2018
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Title: Study of Small Dense Low Density Lipoprotein Cholesterol, Paraoxonase1, and Lipid Profile in Postmenopausal Women

Authors: Dr Shyam Khanderao Kulkarni, Dr Abhay John, Dr Rahul Kunkulol, Dr Sayyed Asif Umar

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i7.138

Abstract

The present study were, to estimate the small dense LDL (sdLDL) cholesterol levels and the Paraoxonase A in postmenopausal women and to correlate the sdLDL –C levels, PON1 activity with menopause. Materials and methods; Present study was carried out in a medical college hospital. Total 40 postmenopausal women were enrolled as cases. These cases were compared with 40 healthy premenopausal women. The parameters studied were small dense LDL-C, paraoxonse1 activity, and lipid parameters (Total cholesterol, triglyceride, HDL-C, LDL-C, and VLDL-C). Results and observation; In present study there is increased concentration of serum triglyceride( 167.52 ± 68.79 vs. 118.95 ± 43.41 mg/dl) which is proven independent risk factor for atherosclerosis. The decreased HDL-C concentration (30.92 ± 7.47vs. 36.67 ± 7.94 mg/dl) suggest altered lipoprotein pattern. The increased concentration of TG is associated with increased sdLDL with no change in LDL-C levels suggesting the menopause related qualitative changes in lipoprotein metabolism. The presence of atherogenicsd LDL with hypertriglyceridemia in postmenopausal women suggest the enhanced lipid transfer reaction, leading to increased synthesis of triglyceride rich and cholesterol poor sdLDL. The significantly increased concentration of sdLDL-C (62.87 ± 17.90vs. 34.25 ± 14.39mg/dl) in postmenopausal women than premenopausal suggest greater atherosclerotic tendency as sdLDL have greater oxidative susceptibility, tendency to accumulate in circulation and lower affinity for LDL receptors. Paraoxonase1, the HDL associated, antioxidant and protective enzyme is found to be low (116.16 ± 76.59 vs. 206.55 ± 69.05U/L) in55postmenopausal women suggestive of decreased antioxidant defense after menopause. The decreased activity of PON1 could be due to lower levels of HDL-C. The decreasing PON1 activity was also found to relate with increased sdLDL.

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Corresponding Author

Dr Abhay John

Assistant Professor, Department of Pharmacology PMT, PIMS