Title: A study on the Electrolytes Imbalance in Leprosy Patients in a Tertiary Care Center

Authors: Dr Prabhakar Singh Bais, Dr Amitabh Agarwal, Dr Priyanka Chauhan

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i7.76

Abstract

Objective: To evaluate the electrolyte imbalance in leprosy patients.

Methods: This was a case-control study. The present study was conducted in a tertiary care hospital. A total of 30 leprosy patients of either gender and 30 controls were included in the study. Blood samples were collected and the serum was separated within 30–45 min, aliquoted and stored at 20C for further analysis. Serum analysis for Na+, and K+, Ca++ and Cl- was performed by the standard methods.

Results: More than one third of cases (40%) and 26.7% of controls were <40 years of age. More than half of cases (60%) and 50% of controls were males. There was no significant (p>0.05) difference in age and gender between cases and controls showing comparability of the groups in terms of age and gender. The serum electrolytes levels sodium and potassium showed decreased level among cases compared to controls (p<0.05).  However, calcium and Cl- increased among the cases than controls (p<0.01).

Conclusion: It was concluded that differences in electrolytes found in leprosy may have a great potential as a diagnostic tool in clinical practice. Electrolyte imbalance has a significant effect upon the risk of contracting many diseases.

Keywords: Leprosy, Electrolyte imbalance, Diagnostic tool.

References

  1. NLEP – Progress Report for the year 2012-13, Central Leprosy Division Directorate General of Health Services Nirman Bhawan, New Delhi.
  2. Suri Sushil kumar K, IyerRekha R, Patel Darshana U, Bandil Supriya, Baxi Seema. Histopathology and Clinico-histopatho-logical correlation in Hansen’s disease. J Res Med Den Sci.2014; 2(1): 37-44
  3. Walker SL, Lockwood DNJ. Leprosy. Clin Dermatol 2007; 25:165–172
  4. Graham A , Furlong S, Margoles LM , Owusu K, Franco Paredes C.Clinical management of leprosy reactions. Infect Dis ClinPract 2010; 18:235–238.
  5. Polycarpou A, Walker SL, Lockwood DNJ.New findings in the pathogenesis of leprosy and implications for the management of leprosy.CurrOpin Infect Dis 2013; 26:413–419.
  6. Thakkar S, Patel SV. Clinical profile of leprosy patients: A prospective study. Indian J Dermatol 2014;59:158-62
  7. Eidt LM. Brevehistória da hanseníase: suaexpansão do mundopara as Américas, o Brasil e o Rio Grande do Sulesuatrajetó-rianasaúdepúblicabrasileira. Saúde Soc. 2004; 13:76–88.
  8. 8-Ridley DS, Jopling WH. Classification of leprosy according to immunity. A five -group system.Int J Lepr Mycobact Dis Off Organ Int LeprAssoc .1966; 34:255–273.
  9. Gaschignard J, Grant A V, Thuc NV, Orlova M, Cobat A., Huong N T, et al. Pauci -and Multibacillary Leprosy: Two Distinct, Genetically Neglected Diseases. PLoS Neglected Tropical Diseases 2016.
  10. Rajat C.S. How electrolyte imbalance causes renal disease or renal disease leads to electrolyte imbalance.2008; Available from, URL: http://renaldisorder.blogspot.com/2008
  11. Lundin Frank E. and Ross Sister Hilary. Electrolyte studies in leprosy. International Journal of Leprosy 1958.
  12. Van Rij AM, Hall MT, Bray JT, Pories WJ. Zinc an integral component of metabolic response to trauma. Journal of Surgery Gynecology and Obstetrics, 1981. 153: 677-682.

Corresponding Author

Dr Amitabh Agarwal

Asso. Prof., Department of Physiology, TSM Medical College & Hospital, Amausi- Lucknow- U.P., India

Mob. No-9780851106, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.