Title: To study the clinical profile of severe plasmodium vivax malaria experience from tertiary care Centre in Agra

Authors: Sanjay Singh, Rameshwar Dayal, Sudeepkumar Singh, Varun Gupta

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i7.72

Abstract

Severe malaria caused by P. vivax infection. Monoinfection by P. vivax can cause severe malaria as seen in P. falciparum.

Aims and Objectives: To study clinical profile of plasmodium vivax patients admitted in tertiary care center inn Agra and there outcome.

Method and Material: This prospective observational study was carried out at F. H. Medical college and Hospital Ethmadpur Agra, included P.vivax positive cases confirmed by both thick and thin blood filmed stained with leishman’s stain for malarial parasite and M.P. Elisa. Detailed history, clinical examination, liver, renal and hematological parameter was done in all patients.

Results: We studied total 180 patients with plasmodium vivax infection out of which 86 males and 94 females. Most patients with age group 21-30 years (63.3%). Severe malaria was present in 56 cases.

Thrombocytopenia (52%) was most common complication followed by hepatic (25%), renal(18.5), cerebral(2.7) involvement.

Conclusions: Severe Plasmodium vivax malaria now very common with increasing renal, liver dysfunction and with altered hematological profile.

Keyword: Plasmodium vivax; liver dysfunction; renal dysfunction; hematological profile.

References

  1. Barbara S, Focus on Plasmodium vivax. Trends Parasitology 2002;18:287–289.
  2. Piscot S, Is Plasmodium vivax still a paradigm for uncomplicatedmalaria? Med Mal Infect 2006;36:406–413.
  3. Milind Y Nadkar, Abhinay M Huchche, Raminder Singh. Clinical Profile of Severe Plasmodium vivax Malaria in a Tertiary Care Centre in Mumbai from June 2010-January 2011. JAPI • october 2012 • VOL. 60
  4. Kochar DK, Saxena V, Singh N, Kochar SK, Kumar SV, Das A, Plasmodium vivax malaria. Emerg Infect Dis 2005;11:132–134.
  5. WHO (2010), p. 35.
  6. Price RN, Tjitra E, Guerra CA. Vivax malaria: neglected and not benign. Am J Trop Med Hyg2007;77(6suppl):79-87.
  7. Andrade B, Reis-Filho A, Souza-Neto SM. Severe plasmodium vivax malaria exhibits marked inflammatory imbalance. Malaria Journal 2010;9:13 doi:10.1186//1475-2875-9-13.
  8. Milind Y Nadkar, Abhinay M Huchche, Raminder Singh. Clinical Profile of Severe Plasmodium vivax Malaria in a Tertiary Care Centre in Mumbai from June 2010-January 2011. JAPI • october 2012 • VOL. 60
  9. Song,chancahal Gera, JasbirDhanoa. Vivax induced ARDS: Report of two cases. J Assoc Physicians India 2010; 58:44-5.
  10. Echeverri M, Alveraz G, Cormona J. Clinical and Laboratory FiindingOf Plasmodium vivax Malaria in Colombia. RerInst Med Trop Sao Poulo 2003;45:29-34
  11. Sarkar D, Ray S, Saha M, Chakraborty A, Talukdar A. Clinico-laboratory profile of severe Plasmodium vivax malaria in a tertiary care centre in Kolkata. Trop Parasitol 2013;3:53-7
  12. Prakash J, Singh AK, Kumar NS, Saxena RK. Acute renal failure in Plasmodium vivax malaria.J Assoc Physicians India 2003;51:265-7.
  13. Syed Munib, Syed Shernaz Jamal. Outcome of haemodialysis inacute renal failure due to malaria: A single centre study. JPMI2006;20:135-8.
  14. Lipin Prasad, Sujathan, Ajith K. Isolated plasmodium vivax malaria associated thrombocytopenia (case report). Clin Biochem 2001;34:341-4.

Corresponding Author

Rameshwar Dayal

Assistant Professor, Department of Medicine

F.H. Medical College, Ethmadpur Agra, India