Follow-up assessment of patients undergoing surgical treatment of Ewing’s sarcoma: An observational study

Title: Follow-up assessment of patients undergoing surgical treatment of Ewing’s sarcoma: An observational study

Authors: Prashant Garhwal, Bimla Choudhary

DOI: https://dx.doi.org/10.18535/jmscr/v6i7.63

Abstract

Background: One of the most common bone cancer affecting the paediatric population and adolescents is Ewing’s sarcoma. Hence; we planned the present study to carry out follow-up assessment of patients undergoing surgical treatment of Ewing’s sarcoma.

Materials & Methods: We planned the present retrospective study on 25 patients with Ewing’s sarcoma of the bone, who underwent surgical treatment for the same. We recorded the complete radiographic investigation details of all the patients from their respective record files. Surgical intervention included resection followed by intercalary reconstruction. Detailed radiographic records of all the patients were obtained on follow-up at different time intervals. All the records were assessed by SPSS software.

Results: ES was present at the extremeties in 24 patients while in a single case, ES was present in the axial location. Deep wound infection was present in single patients while superficial wound infection was present in 2 patients on follow-up. Local recurrence was seen in 1 patient. Recurrence with distant metastasis was found to be present in 1 patient. Implant failure occurred in 1 patient.

Conclusion: Improvement in the prognosis of patients with ES occurs in patients when adequate adjuvant chemotherapy, radiotherapy and surgery are used.

Keywords: Ewing Sarcoma, Surgical, Treatment.

References

Jürgens H, Exner U, Gadner H, Harms D, Michaelis J, Sauer R, et al. Multidisciplinary treatment of primary Ewing’s sarcoma of bone. A 6-year experience of a European Cooperative Trial. Cancer. 1988;61:23–32.

Cotterill SJ, Parker L, Malcolm AJ, et al. Incidence and survival for cancer in children and young adults in the North of England, 1968–1995: a report from the Northern Region young persons’ malignant disease registry. Br J Cancer 2000;83:397–403.

Juergens H, Manner D, Gerss J, Ranfit A, Paulussen M, Dirksen U. TNM staging in Ewing sarcomas. Pediatr Blood Cancer. 2009;5:759.

Huvos AG. Ewing’s sarcoma. In: Huvos AG, ed. Bone tumors: diagnosis, treatment and prognosis, 2nd ed. Philadelphia PA: Sanders, 1991:523–52.

Grier HE, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, Pritchard DJ, et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermaltumor of bone. N Engl J Med. 2003;348:694–701. Hutter RVP, Francis KC, Foote FW. Ewing’s sarcoma in siblings. Am J Surg 1964;107:598.

Craft AW, Cotterill SJ, Bullimore JA, Pearson D. Long-term results from the first UKCCSG Ewing’s Tumour Study (ET-1).United Kingdom Children’s Cancer Study Group (UKCCSG) and the Medical Research Council Bone Sarcoma Working Party. Eur J Cancer. 1997;33:1061–9.

Craft A, Cotterill S, Malcolm A, Spooner D, Grimer R, Souhami R, et al. Ifosfamide-containing chemotherapy in Ewing’s sarcoma: The Second United Kingdom Children’s Cancer Study Group and the Medical Research Council Ewing’s Tumor Study. J ClinOncol. 1998;16:3628–33.

Ladenstein R, Pötschger U, Le Deley M, Whelan J, Paulussen M, Oberlin O, et al. A prognostic score at diagnosis for Ewing tumor patients with metastatic disease at extrapulmonary sites. J ClinOncol. 2009;27:10544.

Tiwari A, Gupta H, Jain S, Kapoor G. Outcome of multimodality treatment of Ewing’s sarcoma of the extremities. Indian Journal of Orthopaedics. 2010;44(4):378-383. doi:10.4103/0019-5413.69307.

Laffosse JM1, Accadbled F, Abid A, Kany J, Darodes P, Sales De Gauzy J. Reconstruction of long bone defects with a vascularized fibular graft after tumor resection in children and adolescents: thirteen cases with 50-month follow-up. Rev Chir Orthop Reparatrice Appar Mot. 2007 Oct;93(6):555-63.

El-Sherbiny M1. Long term behavior of pedicled vascularized fibular grafts in reconstruction of middle and distal tibia after resection of malignant bone tumors. J Egypt Natl Canc Inst. 2008 Jun;20(2):187-95.

Corresponding Author

Dr Bimla Choudhary

Senior Resident, Department of Gynaecology

Government Medical College, Sikar, Rajasthan, India

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