Title: Histomorphological Spectrum of Hepatic Lesions in Liver Biopsies – A Prospective Hospital Based Study

Authors: Shivani Gandhi, Arvind Khajuria, K.C. Goswami

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i7.54

Abstract

Background: Liver is vulnerable to a wide variety of metabolic, toxic, circulatory insults. Microscopic examination of liver biopsy specimen remains the gold standard for the diagnosis of majority of the hepatic diseases.

Methods: A one year prospective study was conducted in the Post Graduate Department of Pathology, ASCOMS & Hospital which included 72 liver biopsies. Each case was analysed with respect to age, gender and histological type.

Results: Out of the total 72 liver biopsy specimen, 86.11% cases were male, 14.28% were females. 33.33% cases were of hepatic tumors, 30.55% of cirrhosis, 11.11% and 9.72% of viral hepatitis and alcoholic hepatitis respectively. Hydatid cystic disease was seen in 2.7% cases and 5.55% cases showed granulomatous hepatitis.

Conclusion: Histomorphological study of liver biopsies help in evaluating the spectrum of various hepatic lesions.

Keywords: Histomorphological spectrum, hepatic lesions, liver biopsy.

References

  1. Pudale S.S, Ashok B.S, Ambadas P.G, Gajanan D.R, Pandharinath C.N. Study of liver pathology in autopsy cases- Original Article. Int J Curr Res. 2014; 6(3): 5795-97.
  2. Desmet V.J., Rosai J. Liver. In: Rosai and Ackerman’s surgical pathology. 10th Milan: Elsevier. 2012: 857-965.
  3. Becker U, Deis A, Sorensen T.I.A., Gronbaek M, Johnsen KB, Muller CF et al. Prediction of Risk of Liver Disease by Alcohol Intake, Sex, and Age: A Prospective Population Study. Hepatology. 1996; 23(5): 1025-29.
  4. Chawla N and Sunila S. Spectrum of Histopathological Findings in Liver Biopsy. Indian Med Gaz. 2013: 363-67.
  5. Abe H, Beninger P.R, Ikejiri N, Setoyama H, Sata M, Tanikawa K. Light microscopic findings of liver biopsy specimens from patients with hepatitis type A and comparison with type B. Gastroenterology. 1982; 82: 938-47.
  6. Ohnishi K., Iida S., Iwana S., Goto N., Nomur F et al. The effect of chronic habitual alcohol intake in the development of liver cirrhosis and Hepatocellular carcinoma in relation to hepatitis B surface antigen carriage. Cancer. 1982; 48: 672-77.
  7. Agrawal NS, Iqbal M.B, Patil AA, Karia KM, Kumar H. Study to Evaluate the Histopathological Spectrum of Hepatic Lesions in Liver Biopsies in a Tertiary Care Hospital. Annals of Pathology and Laboratory Medicine. 2018; 5(3): 228-33.
  8. Agha A, Furnari M, Chakik RM, Ali MMA, Alsaudi D et al. Hepatocellular Carcinoma Is the Most Frequent Final Diagnosis of Focal Liver Lesions Identified in a Cross- Sectional Evaluation of Patients with Chronic Liver Disease in Saudi Arabia. Journal of Cancer Res. 2015.
  9. Gall EA. Posthepatic, post necrotic and nutritional cirrhosis: A pathologic analysis. Am J Pathol. 1960; 36: 241-70.
  10. MacSween RNM, Scott AR. Hepatic cirrhosis: A Clinicopathological review of 520 cases. J Clin Pathol. 1973; 26: 936-42.
  11. Kringsholm B, Christoffersen P. Liver pathology in fatal drug addiction. Forensic Sci Int. 1982; 20(2): 141-51.
  12. Passarino G, Ciccone G, Siragusa R, Tappero P, Mollo F. Histopathological findings in 851 autopsies, with toxicological and virological correlations. Am J Forensic Med Pathol. 2005; 26(2): 106-16.

Corresponding Author

Dr Shivani Gandhi

Post Graduate, Department of Pathology,

Acharya Shri Chander College of Medical Science & Hospital,

Sidhra, Jammu (J&K), India

Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Phone: +91-9796651403