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Category: Volume 06 Issue 06 June 2018
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Title: The effect of single dose of preoperative dexamethasone on postoperative nausea and vomiting after laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled study

Authors: C.P.Pandey, Gopal Krishan, Atul Shishodia, C.G.S. Chauhan, Amit Kukreti, Gaurav Kumar

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i6.165

Abstract

Objective: To study the efficacy of single dose of preoperative dexamethasone in the  prevention of  postoperative  nausea  and  vomiting  in  patients  undergoing laparoscopic  cholecystectomy.

Materials and Methods: 110 patients were randomized in two equal groups. Each of the groups received either 2ml (8mg) intravenous dexamethasone (Group A) or 2ml intravenous normal saline as placebo (Group B).

Results:  6  patients (14.5%) in  group A and 19 patients (34.5%) in  group B had postoperative nausea  and vomiting in first 6 hours whereas  2  patients (3.6%) in group A and 5 patients (9.0%) in  group B had postoperative nausea  and vomiting in  6-24  hours.

Conclusion: Preoperative dexamethasone improves the surgical outcome by reducing disabling symptoms of nausea and vomiting without apparent side-effects. So we suggest that single dose of preoperative dexamethasone should be used as a routine in patients undergoing elective laparoscopic cholecystectomy.

Keywords:  Cholelithiasis, Dexamethasone, Laparoscopic cholecystectomy, Postoperative nausea and vomiting.

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Corresponding Author

Dr Gopal Krishan

Assistant Professor, Department of Anaesthesiology, RMCH Bareilly, UP, India

Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Telephone No.:8979341741