Title: Study of Morphological Features of Carcinoma of Breast in Relation to ER/PR and Her2/neu Status
Authors: Dr Shikha Ghanghoria, Dr C.S. Chhattrasal, Prof. Dr C.V. Kulkarni, Dr Kundan Singh Sisodiya, Dr Manish Kaushal, Dr Ishrat Jahan
DOI: https://dx.doi.org/10.18535/jmscr/v6i6.150
Abstract
Introduction: Breast cancer in India is the most common cancer among women in the urban areas and ranks second in the rural population. In this study our aim is to correlate the morphological features of breast carcinoma with hormone receptor status.
Objectives: To study the morphological features of carcinoma of breast in relation to ER/PR and Her2/neu status.
Materials and Methods: A prospective study conducted from 2016 to 2017 in the Department of Pathology, M.G.M medical college and M.Y Hospital, Indore. 50 cases of carcinoma breast were studied for morphological features and their relation to hormone receptor status.
Results: In present study total 50 patients ranging from 20 to 80 years of age , with 32 (64%)premenopausal and 18 (36%) post menopausal females. Right breast, was most frequently involved (64% cases). Most common size of tumour ranged between 2 to 5cm. Most common histological type of breast carcinoma was invasive ductal carcinoma NOS (not otherwise specified) (90.0%).Both premenopausal and postmenopausal cases showed triple negative as the most common pattern. Among the invasive ductal carcinoma cases, triple negative was the most common pattern. Most common tumour grade in the present study group was grade II and triple negative was the most common pattern in this group.
Conclusion: The breast cancer cases if diagnosed at earlier stage have more favourable prognosis. Increasing the awareness in the public and good programs for early detection of the disease will go a long way in reducing breast cancer.
Keywords: Breast carcinoma, Immunohistochemistry, Morphology and Triple markers.
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