Title: Histopathological Analysis of Liver Lesions in 80 Liver Biopsy Specimens
Authors: Dr Medha Pradeep Kulkarni, Dr Kalpana Ranjitsingh Sulhyan, Dr Deepika Hanumanprasad Yadav, Dr Snehal Hanmantrao Anantwar
DOI: https://dx.doi.org/10.18535/jmscr/v6i6.148
Abstract
Background: Liver biopsy serves an important role in the definitive diagnosis of liver diseases, determining the grade and stage of the disease and also in evaluating the effect of therapy. It is particularly useful in the diagnosis of biliary atresia.
Material and Methods: 80 percutaneous liver biopsy specimens received in our department over a period of August 2014 to Jan 2018 were studied. Biopsy findings were correlated with biochemical investigations and clinical features.
Result: 59 out of 80 cases were neoplasms with 35 metastatic tumors, 22 hepatocellular carcinomas and one case each of non Hodgkin lymphoma and hemangioma. Out of 35 metastatic tumors, 28 were adenocarcinomas along with two cases each of gastrointestinal stromal tumors and squamous cell carcinoma and one case each of malignant melanoma, adenosquamous carcinoma and malignant small round cell tumor. Non neoplastic lesions included seven cases of cirrhosis and four congenital lesions consisting of three cases of biliary atresia and one case of neonatal hepatitis. We had two cases of glycogen storage disease and one case each of fatty change and abscess.
Conclusion: The present study showed that hepatic tumors are the most common lesions encountered on liver biopsy. Metastatic tumors especially adenocarcinomas are much more frequent than primary hepatic tumors. Biopsy of the liver is considered gold standard for histopathological characterization of congenital lesions like biliary atresia and storage disorders.
References
- Rocky DC, Calwell SH et al. Liver biopsy. Hepatology; 2009
www. Interscience. wiley.com .
- Geller SA, Petrovic LM.(Eds) : Biopsy interpretation of the liver. 2nd edition, Lippincott Williams and Wilkins: Philadelphia; 2009
- Hamilton SR, Aaltonen LA.(Eds): World Health Organisation Classification of Tumours. Pathology and Genetics of Tumours of the Digestive system. IARC Press : Lyon; 2000.
- Rosai J.(Editor) : Rosai and Ackerman’s surgical Pathology. 10th edition, Elsevier: Gurgaon 2014.
- Mills SE, Greenson JK, Hornick JL, Longacre TA, Reuter VE (Eds). Sternberg’s Diagnostic Surgical Pathology Lippincott Williams and Wilkins. Philadelphia: 2015.
- Crawford JM. Basic mechanisms in hepatopathology. In Burt AD, Portman BC, Ferell LD (Eds) Macksween’s pathology of the liver. Churchill Livingstone Elsevier: China ; 2007.
- Chawla N, Sunila S. Spectrum of Histopathological Findings in Liver Biopsy. Indian Medical Gazette .2013; 363-7.
- Zahir ST, Aalipour E, Vakili M, Gane MD. Clinicopathological features of liver tumours: A Ten-year Study. J Ayub Med Coll Abbottabad 2015: 27; 775 – 9.
- Ugiagbe EE, Udoh MO. The histopathological pattern of liver biopsies at the University of Benin Teaching Hospital.Nigerian Journal of Clinical Practice 2013;16: 525- 9.
- Lamps LW, Misdraji J, Yerian L, Deshpande V(Eds): Diagnostic pathology, Hepatobiliary and Pancreatic. Amirsys Publishing: Canada ; 2011.
- Stocker JT,Husain AN, Dehner LP, Chandra SR.( Eds): Pediatric Pathology. Lippincott Williams and Wilkins: Philadelphia; 2002.
- Dehghani SM, Haghighat M, Imanieh M, Geramizadeh B, Eskandari Z, Erfanifar F et al. Percutaneous Needle Biopsy in the Diagnosis of Liver Diseases in Children. Journal of comprehensive pediatrics: 2013;4: 184-8.
- Panchal JC, Patel SV. Liver biopsy & its usefulness in pediatric practice.IJSR2013 : 2 ; 177- 9.
- Koshy A et al. Glycogen storage disease: report of 17 cases from southern India. Indian J Gastro 2006;25:182-4.
- Umesh BR, Gayatri BN, Harendrakumar ML. Spectrum of liver pathology at autopsy. Int J Res Rev 2015: 2;79 – 86
- Amrapurkar A, GhansarT ; Fatty liver: Experience from western India. Annals of 2007: 6; 37 – 40
- Metkar GS. Hepatic steatosis: an aetiopathological study. J. Evolution Med. Sci.2016:5; 3502-5.