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Category: Volume 06 Issue 06 June 2018
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Title: Evaluation of the Prevalence of Vertical - Transmission and its correlation with some Haematological variables Among Ante-natal Attendees in Port- Harcourt

Authors: Ngowari Golden, Eze Evelyn M.1, Buseri F.I.

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i6.68

Abstract

Vertical transmission of HIV is the third most common way in which HIV is transmitted worldwide and one of the biggest challenges of the HIV/AIDS disease especially in undeveloped countries. The purpose of this study is to determine the prevalence of vertical transmission of HIV infection among ante-natal attendees in two major hospitals in Port Harcourt and hence the effectiveness of the prevention of mother-to-child transmission programme in these centers.  To effectively carry out this study, the HIV sero-status of ante-natal mothers between April 2015 – May 2016 (4,262 for both BMSH and UPTH at the first instance) and the HIV exposed infants were determined using  various  screening techniques according to the National Algorithm of HIV testing and the HIV-DNA Polymerase Chain Reaction technique on dried blood spots with Q1Aamp DNA mini kit for the babies, the ABO/Rh type of the mother/baby pairs using standard tube technique were determined, the packed cell volume of mothers were determined using haematocrit centrifuge, and the Hb genotype of the mothers/baby pairs were determine using Hb electrophoresis technique. The outcome of the various investigations were subjected to statistical package for social science (SPSS) software (version 17.0, SPSS Chicago, USA) which showed an overall sero-prevalence rate of 4.34% (185/4262) for the mothers and 7.57%(14/185)  for the babies, 3.8% of the women were anaemic, 62.2% were blood group 0, 25.4% A, 9.7% B and 2.7% AB while the Rh analysis showed 60% O positive, 2.2% O negative, 23.2% A positive, 2.2% A negative 9.2% B positive, and 0.5% B negative, 1.6% AB positive and 1.1% AB negative.  Overall 94% were Rh D positive and 6% were Rh D negative, the Hb genotype revealed 79% AA, 19.5% AS and 0.5% SS.  This data could serve as a baseline to monitor the trend of the disease and hence eliminate the incidence of the disease.

Keywords: HIV, Vertical transmission, anti-natal care, Port Harcourt.

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Corresponding Author

Ngowari Golden

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