Title: Prevalence of Hypothyroidism in Major Psychiatric Disorders in Patients Attending Outpatient Department

Authors: Dr Anshu Hotani, Dr Neha Ramsinghani Hotani

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i6.30

Abstract

Background: Defecieny of thyroid hormone leads to hypothyroidism. There is relationship between the major psychiatric disorders and hypothyroidism.

Objective: To determine the prevalence of hypothyroidism in patients attending outpatient department for major psychiatric disorders.

Material and Methods: A descriptive cross-sectional study was conducted on 75 patients attending outpatient department with primary diagnosis of major psychiatric disorders (major depression, bipolar affective disorder, generalised panic disorder, panic disorder, mixed anxiety-depressive disorder, and schizophrenia). Thyroid stimulating hormone (TSH) was performed to assess the evidence of hypothyroidism.

Results: The overall prevalence of hypothyroidism was found to be 10.3% (95%CI, 5–16%). It was 12.5% in anxiety disorder, 11.1% in depressive disorder, with a lower prevalence of 10.3% for bipolar disorder, and 9.9% for schizophrenia.

Conclusions: The overall prevalence of hypothyroidism was found to be less than in the general population, which is between 4.64% and 18.5%, and hypothyroidism was found in disorders other than depression.

References

  1. Sadock BJ, Sadock VA. Synopsis of psychiatry. Lippincott Williams & Wilkins; 2003.
  2. De Arce Cordón MdeR. Funcion tiroidea en pacientes psiquiátricos ingresados (Tesis doctoral). Madrid: Universidad Autónoma de Madrid. Available from: https://repositorio. uam.es/bitstream/handle/10486/11502/57417 arce cordon mar%C3%ADa del rosario.pdf?sequence=1
  3. Gunnarsson T, Sjöberg S, Eriksson M, Nordin C. Depressive symptoms in hypothyroid disorder with some observations on biochemical correlates. Neuropsychobiology. 2001;43:70–4.
  4. Berlin I, Payan C, Corruble E, Puech AJ. Serum thyroid stimulation hormone concentration as an index of severity of mayor depression. Int Neuropsychopharmacol. 1999;2:105–10.
  5. Thomsen AF, Kvist TK, Andersen PK, Kessing LV. Increased risk of developing affective disorder in patients with hypothyroidism: a register-based study. Thyroid. 2005;15:700–7
  6. Cowdry RW, Wehr TA, Zis AP, Goodwin FK. Thyroid abnormalities associated with rapid-cycling bipolar illness. Arch Gen Psychiatry. 1983;40:414–20.
  7. Chang KD, Keck PE, Stanton SP, McElroy SL, Strakowski SM, Geracioti TD. Differences in thyroid function between bipolar manic and mixed states. Biol Psychiatry. 1998;43:730–3.
  8. Posada-Villa J, Buitrago-Bonilla J, Medina-Barreto Y, Rodríguez-Ospina M. Trastornos de ansiedad según distribución por edad, género, variaciones por regiones, edad de aparición, uso de servicios, estado civil y funcionamiento/discapacidad según el Estudio Nacional de Salud Mental-Colombia. Nova. 2006;4
  9. Brabant G, Beck-Peccoz P, Jarzab B, Laurberg P, Orgiazzi J, Szabolcs I, et al. Is there a need to redefine the upper normal limit of TSH. Eur J Endocrinol. 2006;154:633–7.
  10. Londono˜ AL, Gallego ML, Bayona A, Landázuri P. Prevalencia de hipotiroidismo y relación con niveles elevados de anticuerpos antiperoxidasa y yoduria en población de 35 y más anos ˜ en Armenia, 2009-2010. Rev Salud Pública. 2011;13.
  11. Escobar M, Villamil M, Ruiz O. Prevalencia de anticuerpos antiperoxidasa y antitiroglobulina en jóvenes con hipotiroidismo subclínico y clínico 2011. Med Lab. 2011;17:351–7.
  12. Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH, et al. Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA. 2004;291:228–38.
  13. Persani L. Central hypothyroidism: pathogenic, diagnostic, and therapeutic challenges. J Clin Endocrinol Metab. 2012;97:3068–78.
  14. Bao S, Oiknine R, Fisher SJ. Differentiating nonthyroidal illness syndrome from central hypothyroidism in the acutely ill hospitalized patient. Endocrine. 2012;42:758–60.

Corresponding Author

Dr Neha Ramsinghani

Senior Resident, NSCB Medical College, Jabalpur, India

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