Title: Association between Serum Sex Hormone Levels in Men with Lower Urinary Tract Symptoms
Authors: Nisha Luhadia, Mustafa Ali, Manish Kumar Gupta
DOI: https://dx.doi.org/10.18535/jmscr/v6i6.25
Abstract
Background: The Lower Urinary Tract Symptoms (LUTS) complex consists of filling or irritative symptoms (Frequency, Urgency, Dysuria, Nocturia, and Odynouria) and voiding or obstructive symptoms (Poor stream, Hesitancy, Terminal dribbling, Incomplete voiding and Overflow incontinence. It affects 15–60% of men aged > 40 years. The prevalence rises markedly with age. Present study was designed to evaluate the association between serum sex hormones in men with LUTS.
Objective: Present study was designed to evaluate the association between serum sex hormones in men with LUTS.
Material and Methods: It was a study of one year duration involving 94 male patients and was carried out in KGMU, Lucknow in the Department of Pathology, presenting at Urology OPD, KGMU, Lucknow with complaints of Lower urinary tract symptoms.
Results: Age of patients ranged from 40 to 79 years. Serum free testosterone values ranged from 0.5 to 34.4 pg/ml. Serum total testosterone levels ranged from 0.70 to 12.68 ng/ml. Serum total estradiol levels ranged from 1.03 to 466.47 pg/ml. Serum dihydrotestosterone values ranged from 222.62 to 3467.29pg/ml.
Conclusion: Significant positive correlation was observed between serum levels of estradiol and LUTS.
Keywords: Lower Urinary Tract Symptoms, sex hormones, nocturia.
References
- Engstrom G, Henningsohn L, Walker- Engstrom ML, Leppert J. Impact on quality of life of different lower urinary tract symptoms in men measured by means of the SF 36 questionnaire. Scand J Urol Nephrol 2006; 40 : 485–94.
- Parsons JK, Mougey J, Lambert L et al. Lower urinary tract symptoms increase the risk of falls in older men. BJU Int 2009; 104 : 63–8.
- Chavalmane AK, Comeglio P, Morelli A, et al. Sex steroid receptors in male human bladder: expression and biological function. J Sex Med. 2010; 7(8): 2698–2713.
- Rosenzweig BA, Bolina PS, Birch L, et al. Location and concentration of estrogen, progesterone, and androgen receptors in the bladder and urethra of the rabbit. Neurourol Urodyn 1995; 14: 87-96
- Miwa Y, Kaneda T, Yokoyama O. Association between lower urinary tract symptoms and serum levels of sex hormones in men. Urology. 2008;72:552-555.
- Rohrmann S, Nelson WG, Rifai N, et al. Serum sex steroid hormones and lower urinary tract symptoms in Third National Health and Nutrition Examination Survey (NHANES III). Urology. 2007; 69:708-713.
- Chun-Hou Liao, Han-Sun Chiang, and Hong-Jeng Yu. Serum Testosterone Levels Significantly Correlate With Nocturia in Men Aged 40-79 Years. Urology 2011; 78: 631–635.
- St. Sauver JL, Jacobson DJ, McGree ME, Girman CJ, Klee GG, Lieber MM and Jacobsen SJ. Associations between Longitudinal Changes in Serum Estrogen, Testosterone, and Bioavailable Testosterone and Changes in Benign Urologic Outcomes. Am J Epidemiol. 2011; 173(7): 787–796.