Details
Category: Volume 06 Issue 06 June 2018
Hits: 1245

Title: Association between Preoperative Anaemia with Post Operative Mortality and Morbidity

Authors: Chandan Tiwari, Gulab Tiwari, Arvind Baghel, Vinod Kumar, Dhananjay Sharma

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i6.17

Abstract

Preoperative Anaemia is an important risk factor for post-operative morbidity and mortality and has been shown to be independently associated with adverse outcome after non-cardiac surgery.Several large observational studies, including over 600,000 patients, have confirmed the presence of an association between pre-operative anemia and poorer post-operative outcomes Anaemia is an independent risk factor for the preoperative and post operative patient in all types of surgery. Several studies had been done to asses anemia as independent risk factors in post operative outcome and also in patients with associated comorbidities also. meta analysis of various  studies and comparison of result of metanalysis had ben done and results interpreted as correction of anemia in all patients is important for better outcome. But specially in surgical patient preoperative correction of anemia should be implemented whenever possible for better surgical and patient outcome.

References

  1. Kassebaum NJ, Jasrasaria R, Naghavi M, et al. A systematicanalysis of global anemia burden from 1990 to 2010. Blood2014; 123: 615-24.
  2. Carson JL, Noveck H, Berlin JA, et al. Mortality and morbidity in patients with very low postoperative Hb levels who decline blood transfusion. Transfusion. 2002; 42:812. [PubMed: 12375651]
  3. Leung JM, Weiskopf RB, Feiner J, et al. Electrocardiographic ST-segment changes during acute, severe isovolemic hemodilution in humans. Anesthesiology. 2000; 93:1004.In Process Citation. [PubMed: 11020755]
  4. Weiskopf RB, Viele MK, Feiner J, et al. Human cardiovascular and metabolic response to acute, severe isovolemic anemia. Journal of the American Medical Association.1998; 279:217. [PubMed: 9438742]
  5. Preoperative anemia and postoperative outcomes after Hepatectomy Samer Tohme1, Patrick R. Varley1, Douglas P. Landsittel2, Alexis P. Chidi1 & Allan Tsung1 1Department of Surgery, and 2Department of General Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh,
  6. Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study Khaled M Musallam, Hani M Tamim, Toby Richards, Donat R Spahn, Frits R Rosendaal, Aida Habbal, Mohammad Khreiss, Fadi S Dahdaleh, Kaivan Khavandi , Pierre M Sfeir, Assaad Soweid, Jamal J Hoballah, Ali T Taher, Faek R Jamali
  7. Preoperative Anemia and Postoperative Outcomes in Immediate Breast Reconstructive Surgery: A Critical Analysis of 10,958 Patients from the ACS-NSQIP Database Karim A. Sarhane, MD, MSc* José M. Flores, MPH†
  8. Le Roux PD, Participants in the International Multi-disciplinary Consensus Conference on the Critical Care Manage-ment of Subarachnoid Hemorrhage: Anemia and transfusion after subarachnoid hemorrhage. Neurocrit Care 15:342–353, 2011
  9. Hare GM, Tsui AK, McLaren AT, Ragoonanan TE, Yu J, Mazer CD: Anemia and cerebral outcomes: many questions, fewer answers. Anesth Analg 107:1356–1370, 2008
  10. Hales M1, Solez K, Kjellstrand C.The anemia of acute renal failure: association with oliguria and elevated blood urea.Pubmed1994;16(1):125-31.
  11. Nima Alan, B.S.,1 Andreea Seicean, M.P.H., Ph.D.,1,2Sinziana Seicean, M.D., Ph.D., M.P.H.,3,4 Duncan Neuhauser, Ph.D.,2and Robert J. Weil, M.D. Impact of preoperative anemia on outcomes in patients undergoing elective cranial surgeryJ Neurosurg 120:764–772, 2014
  12. Izaks GJ, Westendorp RG, Knook DL. The definition of anemia in older persons. JAMA1999;281:1714–1717. [PubMed: 10328071]
  13. Salive ME, Cornoni-Huntley J, Guralnik JM, et al. Anemia and hemoglobin levels in older persons:relationship with age, gender, and health status. J Am Geriatr Soc 1992;40:489–496. [PubMed:1634703]
  14. Ania BJ, Suman VJ, Fairbanks VF, et al. Incidence of anemia in older people: an epidemiologic studyin a well-defined population. J Am Geriatr Soc 1997;45:825–831. [PubMed: 9215333]
  15. The TIFDED Study Group. Thromboprophylaxis in hip fracture surgery: a pilot study comparing danaparoid, enoxaparin and dalteparin. Haemostasis 1999;29:310–317. [PubMed: 10844404]
  16. Horwich TB, Fonarow GC, Hamilton MA, et al. Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advance heart failure. J Am Coll Cardiol 2002;39:1780–1786. [PubMed: 12039491]
  17. Caro JJ, Salas M, Ward A, et al. Anemia as an independent prognostic factor for survival in patients with cancer: a systematic, quantitative review. Cancer 2001;91:2214–2221. [PubMed: 11413508]
  18. Sullivan P. Associations of anemia, treatments for anemia, and survival in patients with humanimmuno-deficiency virus infection. J Infect Dis 2002;185 (suppl 2):S138–S142. [PubMed: 12001035
  19. Carson JL, Poses RM, Spence RK, et al. Severity of anaemia and operative mortality and morbidity. Lancet 1988;1: 727–729. [PubMed: 2895260]
  20. Carson JL, Duff A, Poses RM, et al. Effect of anaemia and cardiovascular disease on surgical mortality and morbidity. Lancet 1996;348:1055–1060. [PubMed: 8874456]

Corresponding Author

Dr Gulab Tiwari

Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Mo no. 7224070682