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Category: Volume 06 Issue 05 May 2018
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Title: Correlations of serum level of 25(OH)D, Parathyroid Hormone (PTH) and Bone Mineral Density (BMD) among chronic patients of Spinal Cord Injury (SCI)

Authors: Dr Minhaj Akhter, Dr Rajeswari Jindal, Dr S.R. Jindal, Dr Kusum Lata Gaur

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i5.160

Abstract

Background: Patients with SCI show mostly osteopenia or osteoporosis of the hip and spine. Vitamin D deficiency and secondary hyperparathyroidism may contribute to development of osteoporosis in SCI cases.

Method: A correlation study was conducted on 100 chronic SCI patients admitted in the Department of Physical Medicine &Rehabilitation, Sawai Man Singh Medical College, Jaipur. After taking information regarding subject and his/her injury, blood samples were collected to investigated for routine biochemistry with serum PTH and serum 25(OH)D. DXA scan of hip and spine was also done. Correlation between 25(OH)D with DXA and with PTH was found by Pearson correlation. Correlation between PTH with DXA was also found by Pearson correlation.

Result: The study revealed that 55% patients had subnormal vitamin D (<20 ng/mL). Positive correlation was found between vitamin D & BMD which was found significant for hip T score but not for spine T score. Whereas negative correlation was found between parathyroid hormone (PTH) & BMD which was found significant with both hip and spine T score. Negative correlation was found between vitamin D & PTH, which was also found significant.

Conclusion: Vitamin D and PTH play important role in SCI cases. So, monitoring of Serum 25(OH)D levels, serum PTH & serum calcium and annual surveillance of bone mineral density is crucial among persons with chronic SCI to reduce progression of osteoporosis and minimize the risk for further fractures.

Keywords: 25 Hydroxy Vitamin D (25(OH)D), Dual Energy X-Ray Absorptiometry (DEA), PTH: Parathyroid Hormone (PTH), Bone Mineral Density (BMD).

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Corresponding Author

Dr Rajeswari Jindal

20 Kailashpuri, Near Jagatpura Rly Station,

Malviyanagar Ext. Jaipur, PIN-302017, Rajasthan, India

Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Mobile No. 09460271172