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Category: Volume 06 Issue 05 May 2018
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Title: Pathogenesis of Type 2 Diabetic Retinopathy by the Epigenetic Modification of 5-Carboxylcytosine DNA Methylation in the CpG Island of Promoter Region of Brain Derived Neurotrophic Factor

Authors: Ambika Prasad Ahirwar, Rigved Tripathi, Pushpendra Kumar Namdeo, Archana Tiwari

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i5.109

Abstract

Worldwide Type 2 Diabetic Retinopathy is one of the leading causes of blindness. It is the most frequently occurring complication of diabetes mellitus and remains a leading cause of vision loss in many countries. Although some potential functions of DNA methylation have been demonstrated already, many questions remain in terms of unveiling the role of 5caC; whether it serves either merely as an intermediate of DNA demethylation or as a stable epigenetic marker. 5-carboxylcytosine (5caC) is proved to be not merely serving as an intermediate of DNA demethylation, but also acts as a stable epigenetic marker. This review define how to control the gene expression and DNA Methylation in the CpGIsl and, The DNA Demethylation leads to convert the 5mc to 5hmc by the TeTprotein and again the 5hmc transfer to 5fc and further 5caC by the TeT enzyme in the BDNF gene. This review show the method to analyze the DNA Methylation at the 5-caC region for the BDNF gene and the fully mechanism which show the demethylation from 5hmc to 5fc and the pathway of DNA Demethylation from cytosine to 5-caC (5-Carboxylcytosine).

Keywords: Epigenetic Modification, DNA methylation, BDNF gene, 5-caC, CpGIs , Diabetic Retinopathy.

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Corresponding Author

Ambika Prasad Ahirwar

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