Title: Prevalence, Clinical and Etiological Profile of Acute Pancreatitis in India: A Single Center Study

Authors: Manohar Lal Prasad, Prajit Mazumdar, Malyaban Das

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i5.62

Abstract

Introduction: Acute pancreatitis is an inflammatory condition of pancreas caused by auto digestion of the gland by its digestive enzymes leading to destruction of the gland. The aim of the study is to assess different epidemiological factors associated with acute pancreatitis.

Materials and Methods: Our study a cross-sectional descriptive study. This study includes a total of 69 patients admitted in the medicine department with acute pancreatitis during the year. A detailed history was taken and radiological, biochemical studies was done to evaluate the patients.

Observation: there was male preponderance. Alcohol was the most common causative factor. Most of the patients were from age group 30-50.Plain radiograph of abdomen was not specific. USG whole abdomen and CECT abdomen was very sensitive. Serum amylase was elevated in all cases. Pain abdomen was most common symptom.

Discussion: discrepancy in sex distribution may be due to difference in hospital admission rate in male and female. Amylase creatinine ratio is very helpful. CECT abdomen has very little advantage over usg in diagnosing acute pancreatitis.

Key words: Acute pancreatitis, Risk factors, Diabetes Mellitus, Retrospective study, Cross-sectional study.

References

  1. Klöppel G and Maillet B. Pathology of acute and chronic pancreatitis. Pancreas 1993;8:659-670.
  2. Witt H, Apte MV, Keim V and Wilson JS. Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy. Gastroenterology 2007;132:1557-1563.
  3. Surbatovic M and Radakovic S. Tumor necrosis factor-α levels early in severe acute pancreatitis: is there predictive value regarding severity and outcome? J ClinGastroenterol2013;47:637-643.
  4. L. Yang, Vadhavkar S, Singh G and OmaryMB.Epidemiology of alcohol-related liver and pancreatic disease in the United States. Arch Intern Med 2008;168:649-656.
  5. Read, G.;Braganza, J.M. and Howat, H.T. : Pancreatitis a retrospective study. Gut. , 17: 945, 1976.
  6. Olsen, H. : Pancreatitis- a prospective clinical evaluation of 100 cases and review of literature. American Journal of Digestive Disease. 18: 1077, 1974.
  7. Tandon, R.; Rai, R.R..; Nundy, S. and Vashist, S.: A study of chronic pancreatitis in the All India Institute of Medical Sciences, New Delhi. In: Chronic pancreatitis in India :Balkrishnan, V., Indian Society of pancreatology, p. 9-14, 1987.
  8. Warshwa, A.L. and Fuller , A.F. : Specificity of increases renal clearance of amylase in diagnosis of acute pancreatitis. N. Eng. J. Med., 292 : 325-8, 1975.
  9. Bapat, R.D.; Nazareth, H.M..; Kulkarni, A.G..; Shah, A.B. : Prognostic markers of acute pancreatitis- aprospective study. Indian Journal of Gastroenterology, 5: 113, 1986.
  10. J.A..; Stanley, R.J. and Berland, L.L. : Diagnosis and treatment. Pancreatic imaging. Annals. Of Int. Med.., 102: 212,1985.
  11. Bhansali, S.K. and Pande, C.K. : Acute Pancreatitis – an appraisal of 42 cases. Am. J. Gatroenyterol.,57; 152-65,1972.

Corresponding Author

Prajit Mazumdar

Department of Medicine, Rajendra Institute of Medical Sciences