Title: Evaluation of Role of Autologous Platelet Rich Fibrin in Wound Healing and Bone Regeneration after Mandibular Third Molar Surgery: A Prospective Study
Authors: Dr Aditya Harsh, Dr Bindu Bhardwaj, Dr Vikas Singh, Dr Ruchika Tiwari, Dr Rajesh Tak, Dr Vidhi Verma
DOI: https://dx.doi.org/10.18535/jmscr/v6i5.33
Abstract
Background: Bony cavities filled with PRF showed healing in the half the time as compared to the time required for physiological healing. Thereby the aim of this study is to evaluate the role of autologous platelet rich fibrin in healing and bone regeneration in mandibular third molar extraction sockets.
Material & Methods: All the selected patients were explained about the procedure, its related complications and the follow-up period involved in the study. The study subjects were carried out in the Department of Oral And Maxillofacial Surgery, Mahatma Gandhi College and Hospital, Jaipur with bilateral impacted mandibular 3rd molars. The subjects were evaluated for pain, swelling and pocket depth on 3rd, 7th and 30th day post-operatively. Pocket depth was measured by using William’s Graduated Probe. 10-Level Visual analog scale was used to evaluate pain.
Results: Our study showed that the pain scores were measured by using VAS. There were no statistically significant differences observed between groups and swelling also statistically significant differences were observed in third days, seventh days and after one month between PRF and control side (p < 0.05). The degree of inflammation which was more on the 3rd post-PRF placement day was also significantly decreased by the after one month (P < 0.05).
Conclusion: We concluded that PRF could be used for control swelling after third molar extraction surgery. Studies with a larger sample that will need a bilateral third molar removal that will be extracted in different sessions with a longer follow-up is warranted to obtain a more statistically meaningful results with respect to bone regeneration.
Keywords: Platelet rich fibrin, impacted third molar, pain, bone regeneration, swelling.
References
- Saluja H, Dehane V, Mahindra U. Platelet Rich Fibrin: A Second Generation Platelet Concentrate and a New Friend of Oral and Maxillofacial Surgeons. Ann Maxillofac Surg. 2011 Jan-Jun; 1(1): 53–7.
- Choukroun J, Adda F, Schoeffler C, Vervelle A. Une opportunité en paro-implantologie: le PRF. Implantodontie. 2001;42:55–62.
- Grossi GB, Maiorana C, Garramone RA, Borgonovo A, Creminelli L, Santoro F. Assesing postoperative discomfort after third molar surgery:A prospective study. J Oral Maxillofacial Surg. 2007;65:901–17.
- Baqain Z, Karaky AA, Sawair F, Khraisat A, Duaibis R, Rajab LD. Frequency estimates and risk factors for post operative morbidity after third molar removal:A prospective cohort study. J Oral Maxillofac Surg. 2008;66(11):2276–83.
- Simonpieri A, Del Corso M, Sammartino G, Dohan Ehrenfest DM. The Relevance of Choukroun’s Platelet-Rich Fibrin and Metronidazole During Complex Maxillary Rehabilitations Using Bone Allograft. Part I: A New Grafting Protocol. Implant Dent. 2009;18:102–111.
- Singh A, Kohli M, Gupta N. Platelet rich fibrin: a novel approach for osseous regeneration. J Maxillofac Oral Surg. 2012;11(4):430–4.
- Kumar N, Prasad K, Ramanujam L, K R, Dexith J, Chauhan A. Evaluation of Treatment Outcome After Impacted Mandibular Third Molar Surgery With the Use of Autologous Platelet-Rich Fibrin: A Randomized Controlled Clinical Study. J Oral Maxillofac Surg. 2014 Dec 13.
- Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate.Part IV: Clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:E56–60.
- Mozzatti M, Martinasso G, Pol R, Polastri C, Cristiano A, Muzio G, et al. The impact of plasma rich in growth factors on clinical and biological factors involved in healing processes after third molar extraction. J Biomed Mater Res. 2010;95(3):741–6.
- Alissa R, Esposito M, Horner K, Oliver R. The influence of platelet-rich plasma on the healing of extraction sockets: an explorative randomised clinical trial. Eur J Oral Implantol. 2010;3(2):121–34.
- Lee JW, Kim SG, Kim JY, Lee YC, Choi JY, Dragos R, et al. Restoration of a peri-implant defect by platelet- rich fibrin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2012;113(4):459–63.