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Category: Volume 06 Issue 05 May 2018
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Title: Evaluation of Vitamin-D Level as an Important Diagnostic Predictor in Progression of Chronic Kidney Disease in Tertiary Care Hospital - A Prevalence Study

Authors: Dr Sangita Biswas, Dr Sujit Kumar Dey

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i5.19

Abstract

Introduction: This study was destined to find out  possible link between progression of Chronic kidney disease (CKD) and vitamin D level which is now very common worldwide specially in third world country like India where scarcity of research made it an emerging public health problem.

Materials and Methods: A total of 70 cases of CKD and 30 normal age, sex matched individuals as controls were taken after satisfying inclusion, exclusion criteria. Semi auto-analyzer to estimate serum creatinine and GFR estimation from the serum creatinine value was done by using Modification of diet in renal disease (MDRD) study equation. Specific reagent kit was used to estimate ACR. Estimation of serum Vitamin D (25-OH-D) was done by enzyme linked immunosorbent assay (ELISA). Correlation between serum Vitamin D level with GFR and ACR value were calculated to comment on role of Vitamin D level in progression of CKD. CKD was graded according to Kidney Disease Improving Global Outcomes (KDIGO) 2012 classification by GFR and ACR.

Results & Conclusion: 71.4% of CKD cases were found to be vitamin D deficient whereas control group showed only 30% prevalence (P<0.001 using Pearson Chi Square test).

Among the CKD cases there were significant deficiency of Vitamin D level with increasing CKD grade (49.9% in G3a, 53.83% in G3b, 68.42% in G4 and 83.48% in G5) (P<0.05 using Pearson Chi Square test).

Keywords: Vitamin D, Chronic kidney disease, GFR, ACR, KDOQI.

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Corresponding Author

Dr Sujit Kumar Dey

Associate Professor, Dept. of Biochemistry, 4th Floor,

Academic Building, R. G. Kar Medical College, 1, Kshudiram Bose Sarani, Kolkata-004, India

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