Title: A Comparative Study of the Efficacy of Intraumbilical Oxytocin and Intravenous Methyergometrine in the third Stage Bleeding

Authors: Dr Deepthy Balakrishnan, Dr P Leelamma

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i4.202

Abstract

Aim: To compare the efficacy of intraumbilical Oxytocin and intravenous Methyl ergometrine in active management of third stage of labour.

Material and Methods: This is a prospective study of 100 cases of singleton low risk pregnancies where 50 cases were allotted at random to group I which included patients who received intraumbilical Oxytocin 10 IU immediately after delivery of the baby. Injection Methylergometrine (0.2 mg) was given intravenously at the delivery of anterior shoulder of the baby to women in Group 2. Outcome measures were the duration of third stage, amount of blood loss, post-delivery hemoglobin and side effects in both groups.

Statistical analysis: The statistical constants like mean, standard deviation and percentage were calculated. The hypothesis formulated was tested statistically by using chi-square test.

Results: There was no statistically significant difference in mean duration of third stage of labour, mean blood loss, post-delivery hemoglobin, need for additional uterotonics or in side effects between the two groups.

Conclusion: Intraumbilical oxytocin is as effective as methylergometrine in reducing the duration of third stage of labour and blood loss and is useful in prevention of postpartum hemorrhage.

Keywords: Postpartum hemorrhage, Active management of third stage of labor, blood loss, duration of third stage.

Key message: Intraumbilical oxytocin can be used in active management of third stage especially in patients with no intravenous access and in high risk  patients.

References

  1. Abou ZC, Wardlaw T. Maternal mortality in 2000: Estimates developed by WHO, UNICEF and UNFPA. Geneva: World Health Organization. 2000.
  2. Maternal mortality: World health organization: Fact sheet. Updated on November 2016.
  3. Mathai M, Gülmezoglu A, Hill S. WHO recommendations for the prevention of postpartum hemorrhage.Geneva: WHO Document Production Services; 2007. pp. 4–5.
  4. Soltan MH, El-Gendi E, Imam HH, et al. Different doses of sublingual misoprostol versus methylergometrine for the prevention of atonic postpartum hemorrhage. Int J Health Sci (Qassim) 2007;1(2):229–23
  5. Dumoulin, J.G. (1981) A Reappraisal of the Use of Ergometrine. Journal of Obstetrics and Gynecology, 1, 178-181.
  6. Embrey, M.P. (1961) Simultaneous Intramuscular Injection of Oxytocin and Ergometrine: A tocographic Study. BMJ, 1, 1737-1738.
  7. McDonald, S., Prendville, W.J. and Elbourne, D. (2001) Prophylactic Syntom-etrine versus Oxytocin for Delivery of the Placenta.
  8. Suellen, M., et al. (2004) A Cochrane Review Metaanalysis. New Advances for Low-Resource Settings: Uterotonics for Prevention of Postpartum Hemorrhage. Journal of Midwifery & Women’s Health, 49, 283-292.
  9. Bugalho, A., Daniel, A., Faundes, A. and Cunha, M. (2001) Misoprostol for Prevention of Postpartum Hemorrhage. International Journal of Gynecology Obstetrics, 73, 1-6. Mudaliar AL Causation and stages of labour.
  10. Mudaliar and Menon’s Clinical Obstetrics, Editors Gopalan S, Rathnakumar S, Jain V. 12th Edition.Hyderabad Universities Press (India) Pvt Ltd: 2015:94-6.
  11. Athavale R D, Nerurkar N M, Dalvi S A, Bhattacharya M S. Umbilical vein oxytocin in the management of third stage of labour. J Postgrad Med 1991; 37:219.
  12. Chestnut D, Oxytocin Wilcox LL. Influence of umbilical vein administration of in the third stage of labour: a randomized double blind placebo –controlled study.Amer J obstet & gynecolo 1987; 157:160-162.
  13. Golan A, (Baruch) Lidor AL, Wexler S, David MP. A new method for management of the retained placenta. Amer J Obstet & Gynecol 1983; 146:708-709.
  14. Güngördük K, Asicioglu O, Besimoglu B, Güngördük OC, Yildirm G, Ark C, Tekirdağ AI. Using intraumbilical vein injection of oxytocin in routine practice with active management of the third stage of labor: a randomized controlled trial. Obstet Gynecol. 2010 Sep; 116(3):619-24.
  15. Reddy Virginia V. et al Effect of umbilical vein oxytocin on puerperal blood loss and length of the third stage of labor. American Journal of Obstetrics & Gynecology, Vol. 160, Issue 1, 206 - 208
  16. Boopathi A, Nayak S, Rao And Rao B. (2014) Oxytocin Versus Methyergo-metrine In The Active Management Of Third Stage Of Labour. Open journal Of Obstetrics and gynecology.4, 666-671.

Corresponding Author

Dr Deepthy Balakrishnan