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Category: Volume 06 Issue 04 April 2018
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Title: Study of prevalence of primary bone tumors at a tertiary care centre in Central India

Authors: Verma Rahul, Gupta Upendra, Uikey Suresh

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i4.104

Abstract

Introduction: Bone sarcomas account for 0.2% of all malignancies. Many relevant demographic, clinical and epidemiological characteristics have been reported.

Objectives: To analyze the spectrum of primary bone tumors and their relative frequency in Gandhi Medical College and Hamidia Hospital, Bhopal.

Methods: This is a three and a half year study conducted from July 2012 to December 2015. All primary bone tumors confirmed by histopathology have been included.

Results: A total of 124 cases of primary bone tumours were studied. Age range varied from 7 to 92 years with a mean age of 24.4 years. Among these, 55.65% were males and 44.35% were females. On histological examination, 51.6% were benign and 48.4% cases were malignant. Giant cell tumor was the commonest benign tumor (39.7%) and osteosarcoma was the commonest malignant tumor (56.7%). Maximum number of cases belonged to the 2nd decade followed by 3rd and 4th decade. Clinically, all patients presented with swelling, hence the most common symptom. 42% patients presented with both pain and swelling.

Conclusion: The pattern and distribution of bone tumors seen at our centre are similar to those reported from other studies. Males were more commonly affected than females with a peak in the second decade of life. Long bones of lower extremity were the most commonly affected sites. Giant cell tumour and osteosarcoma were the commonest benign and malignant varieties respectively.

Keywords: Bone tumors, sarcoma, prevalence.

References

  1. Dorfman HD, Czerniak B, R. K. WHO classification of tumours of bone. 2002. 225-367 p.
  2. Franchi A. Epidemiology and classification of bone tumors. Clin Cases Miner Bone Metab. 2012;9(2):92–5.
  3. Sakala D, Munthali JC, Mulla Y. Primary Malignant Bone Tumours at the University Teaching Hospital in Lusaka Zambia. Med J Zambia. 2016;43(1):24–30.
  4. Niu X, Xu H, Inwards CY, Li Y, Ding Y, Letson GD, et al. Primary bone tumors: Epidemiologic comparison of 9200 patients treated at Beijing Ji Shui Tan Hospital, Beijing, China, with 10 165 patients at Mayo Clinic, Rochester, Minnesota. Arch Pathol Lab Med. 2015;139(9):1149–55.
  5. Rhutso Y, Laishram R, Sharma LdC, Debnath K. Histopathological evaluation of bone tumors in a tertiary care hospital in Manipur, India. J Med Soc. 2013;27(2):135.
  6. Abdulkareem FB, Eyesan, S U. Pathologic study of bone tumours at the National Orthopaedic Hospital, Lagos, Nigeria. West Afr J Med. 2007;26(4):306–11.
  7. Jain K, Sunila, Ravishankar R, Mruthyunjaya, Rupakumar CS, Gadiyar HB, et al. Bone tumors in a tertiary care hospital of south India: A review 117 cases. Indian J Med Paediatr Oncol. 2011;32(2):82–5.
  8. Gupta D, Gupta RK, Gupta RK. Study of the morphological pattern of non-neoplastic and neoplastic bone lesions- a 5 year study. Indian J Pathol Oncol. 2016;3(2):165–73.
  9. Bamanikar S, Pagaro P. Histopathological Study of Primary Bone Tumours and Tumour-Like Lesions in a Medical Teaching Hospital. J Krishna Inst Med Sci Univ. 2015;4(2):46–55.
  10. Larsson S, Lorentzon R. The incidence of Malignant primary bone tumours in relation to age, sex and site. J bone Jt Surg. 1974;56 B(3).
  11. Price CHG, Jeferee GM. Incidence of bone sarcoma in sw england, 1946-74, in relation to age, sex, tumour site and histology. Br J Cancer. 1977;36:511–22.
  12. Oyemade GAA, Abioye AA. Primary Malignant tumors of bone: Incidence in Ibadan, Nigeria. J Natl Med Assoc. 1982;74(1):65–8.
  13. Arora RS, Alston RD, Eden TOB, Geraci M, Birch JM. The contrasting age-incidence patterns of bone tumours in teenagers and young adults: Implications for aetiology. Int J Cancer. 2012;131(7):1678–85.
  14. Garciadiego-cázares D, Rubio RD. Epidemiological Aspects of Osteosarcoma , Giant Cell Tumor and Chondrosarcoma Musculoskeletal Tumors - Experience of the Epidemiological Aspects of Osteosarcoma , Giant Cell Tumor and Chondrosarcoma Musculoskeletal Tumors - Experience of the National Reha. Asian Pac J Cancer Prev. 2015;15(August 2016):6451–5.
  15. Rc Petca, Gavriliu S, Burnei G. Retrospective clinicopathological study of malignant bone tumors in children and adolescents in Romania – single center experience. J Med Life. 2016;9(2):205–10.
  16. Patel D, Patel P, Gandhi T, Patel N, Patwa J. Clinicopathological study of bone lesions in tertiary care center – a review of 80 cases. Int J Adv Res. 2015;3(7):1267–72.
  17. Hathila R, Mehta J, Jha B, Saini P, Dudhat R, Shah M. Analysis of bone lesions in tertiary care center - A review of 79 cases. Int J Med Sci Public Heal. 2013;2(4):1037.
  18. Sharma S, Mehta NP. Histopathological Study of Bone Tumors. Int J Sci Res. 2015;4(12):2014–6.

Corresponding Author

Gupta Upendra

Senior Resident, Department of Orthopedics,

Gandhi Medical College, Bhopal