Title: Observational Study of Renal Function in children with Sickle Cell Disease: in a Tertiary Care Hospital of Jharkhand
Authors: Rajeeva Mishra, Dilip Kumar, Anil Kumar Choudhary, Arvind Kumar, Akhilesh Kumar, Sweety Kumari
DOI: https://dx.doi.org/10.18535/jmscr/v6i4.54
Abstract
Background: Sickle cell disease has been reported from all over the world including India. The early detection of sickle cell nephropathy & its treatment is essential for improving quality of life in these children.
Objective: Current study aims at to study the features of renal involvement in sickle cell disease patients.
Materials & Method: 81 consecutive cases admitted to hospital with sickle cell disease were studied by history, thorough examination & stepwise investigations including urine routine examination, culture-sensitivity & concentration test; Blood urea and serum creatinine.
Results: The mild proteinuria, microscopic hematuria, pyuria and casts had been noted in 19.5% (16 cases), 14.8% (12 cases), 19.5% (16 cases) and 4.9% (4 cases) of sickle cell disease patients respectively. The concentrating capacity of the tubules was significantly affected in children with sickle cell disease in elderly age groups. But no significant changes were observed in the younger children, in the age group of 2 to 5 years.
Conclusion: There is a significant impairment in concentrating capacity of kidney with increasing age among sickle cell disease patients but no difference in earlier age group.
Keywords: Sickle cell nephropathy, hyposthenuria.
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