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Category: Volume 06 Issue 03 March 2018
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Title: Type 1 Diabetes mellitus and Neurofibromatosis 1: A Rare Association (Case Report)

Authors: Mohamed Amin Gebreel MD, Amira Ali Zaakok MD, Hazem Mohamed Skr MSC, Mohamed Elsayed Abudagher MSC, Ameer Sobhi Eldeep MSC

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i3.204

Abstract

Neurofibromatosis type 1 is a genetic disorder with abnormalities of the nervous tissue, bones, skin and soft tissues .It allows the growth of tumors along the nerves of bone, skin and brain. It is rarely associated with diabetesmellitus. We reported a case with neurofibromatosis type 1 and type 1 diabetes mellitus.

Keywords: Neurofibromatosis type 1 .diabetes mellitus

References

  1. Friedman JM. Neurofibromatosis 1. 1998 Oct 2 [updated 2014 Sep 4]. In: Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Ledbetter N, Mefford HC, Smith RJH, Stephens K, editors. GeneReviews® [Internet]. Seattle (WA): 1993-2017. http://www.ncbi.nlm.nih.gov/books/NBK1109/  Citation on PubMed
  2. Rauen K .The RA Sopathies. Annu Rev Genomics Hum Genet2013;14:355-69. doi: 10.1146/annurev-genom-091212-153523.
  3. Hsieh DT. Neurofibromatosis Type 1. Medscape Reference. July 27, 2016; http://emedicine.medscape.com/article/1177266-overview.
  4. Abbas A. Disease caused by immune responses: hypersensitivity and autoimmunity. In: Abbas A, Lichtman H, editors. Cellular and molecular immunology.5th edition. Philadelphia: Saunders; 2005. p. 411 -31
  5. Williams V, Lucas j, Babcock M, Gutmann D ,Bruce B, Maria B.“ Neurofibromatosis type 1 revisited,” 2009; Jan;123(1):124-33. https://doi.org/10.1542/peds.2007-3204
  6. Ozhan B, Ozguven A, Ersoy Neurofibromatosis Type 1 and Diabetes Mellitus:Case Reports in Endocrinology Volume 2013, Article ID 689107, 3 pages.
  7. Korf B. Neurofibromatosis type 1 (NF1): Pathogenesis, clinical features and diagnosis. UpToDate.June 2015; Accessed 7/19/2015.
  8. Jett K, Friedman J. Clinical and Genetic Aspects of Neurofibromatosis 1. Genetics in Medicine, Genet Med.2010: Jan;12(1):1-11https://doi.org/10.1097/GIM.0b013e3181bf15e3
  9. Tekin F, Carcurgan S, Ilter T. “Autoimmunehaemolysis as an unusual cause of anaemia in von Recklinghausen's disease,” Neth J Med.2004 Oct;62(9):337-9.
  10. Zaka-ur-Rab Z ,Chopra K. “Diabetes mellitus in neurofibromatosis I:an unusual presentation,” Indian Pediatrics, (2005) ;42,:185–6
  11. Bhandari R, Riddiough G, Lokan J, Weinberg, L,E fthymiou M, NikfarjamM. Somatostatinoma of the minor papilla treated by local excision in a patient with neurofibromatosis type 1. JOP.2015 ;Jan 31.16(1):81-4.doi:10.6092/1590-8577/2906
  12. Williamson, J, Thorn C, Spalding,D, Williamson ,C. Pancreatic and Peripancreatic somatostatinomas.  Ann R CollSurg Engl. 2011 Jul. 93(5):356-60.
  1. Ellison T, Edil B. The current management of pancreatic neuroendocrine tumors. Adv Surg. 2012; 46:283-96.
  2. Neoplasms of the endocrine pancreas. Greenfield J, Mulholland W, Oldham T, eds. Surgery: Scientific Principles and Practice. 3rd ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2001; 899-13.
  3. Kamoun, M., Charfi N., Rekik ,N., “Neurofibromatosis and type 1 diabetes mellitus: an unusual association: letters: original observations,” 2009; Diabetic Medicine,( 26)1180–1.

Corresponding Author

Mohamed Amin Gebreel MD

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