Title: Comparative Study of the Effect of Oral Omeprazole with Oral Ranitidine on pH and Volume of Gastric Aspirate in Patients Undergoing Elective Surgery
Author: Dr GANGA, G MD, DA
DOI: https://dx.doi.org/10.18535/jmscr/v6i3.184
Abstract
Background: The risk of regurgitation and vomiting with subsequent pulmonary aspiration of gastric contents has been recognized as a serious hazard. Various pharmacological agents are being used to minimize the risk of acid aspiration.
The objectives of this present study are to compare the efficacy of omeprazole and ranitidine in reducing the volume of gastric fluid and to compare the efficacy of omeprazole and ranitidine in increasing the pH of gastric fluid in patients undergoing elective surgery.
Material and Methods: After Obtaining institutional approval and individual consent 60 patients were randomly selected into III groups of 20 each in the randomized comparative study. The group I as control, group II received 40mg omeprazole and III received 150 mg ranitidine night before and 6am on the day of surgery. All the patients were given premedication of injection phethidine 1mg/kg . General anesthesia is induced and when a steady state is achieved an 18 FG nasogastric tube well lubricated with ligonocane jelly is passed in to the stomach. Volume of gastric fluid and PH of the aspirate is collected using 20 ml syringe and pH measured by pH paper.
Result: The patients characteristics and demographic data were comparable in the 2 groups. It is proved beyond doubt that both the treatment groups were definitely superior to the control group in increasing the gastric PH and as well as reduce the gastric volume.
Conclusion: The omeprazole group is found to be effective adjuvant to safe anesthesia practice. It should be routinely included in pre anesthetic preparation of all elective surgery patients under general anesthesia to prevent the dreaded complication of acid aspiration pneumonitis
Keywords: Omeprazole, Ranitidine, Gastric aspirate
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