Title: Quantitative Estimation of Salivary Biomarkers in Diabetic and Non-Diabetic Individuals
Authors: Dr Ronak Kabra, Dr Garima Bhatt, Dr Meenakshi Meena, Dr Rahul Kasat, Dr Payal Dhaka, Dr Gaurav Chari
DOI: https://dx.doi.org/10.18535/jmscr/v6i3.177
Abstract
Background: Saliva as a diagnostic tool, is gaining attention world-wide. The value of saliva as an indicator of systemic disease has also been explored. Oral physicians hold the responsibility of recognizing significant associations between certain oral anomalies and diabetes mellitus. The aim of the present study is to assessed the salivary levels of amylase, albumin, glucose, total protein and c-reactive protein in individuals having chronic periodontitis with and without diabetes.
Material & Methods: Patients visiting the department of Periodontology on an out-patient basis at Darshan Dental College and Hospital, Udaipur, Rajasthan were included in the study. Total 26 patients, 13 patients with chronic periodontitis with type II diabetes (group A), 13 patients with chronic periodontitis without diabetes (group B) were included in the study after obtaining written consent. After periodontal recordings and Hba1c reports, Saliva sample was collected from patients at baseline for evaluation of salivary amylase, albumin, total protein, c-reactive protein and glucose levels.
Results: Our study showed that the mean value of glucose, total protein and albumin in saliva was higher in group A as compared to group B, which was statistically significant (P<0.05. P<0.01 & P<0.05 respectively). The mean value of C-reactive protein and amylase was slightly higher in group A as compared to group B, which was statistically non- significant (P=1.26 & P=0.34 respectively.
Conclusion: Diabetes mellitus has been consistently documented to be associated with altered salivary composition and function. Although many studies have been carried out on salivary parameters in diabetes, our study will be one of the very few that will assess all the salient parameters and variables affecting them in a single cohort.
Keywords: Diabetes mellitus, Salivary biomarkers, HbA1c, Periodontitis.
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