Title: Effect of Conventional Phototherapy on platelet count in full term and Preterm Neonates with Indirect Hyperbilirubinemia - A Prospective Cohort Study
Authors: Prashant Sonawane, Baraturam Bhaisara, Anjali Bhatawdekar
DOI: https://dx.doi.org/10.18535/jmscr/v6i3.160
Abstract
Jaundice in newborn is quite common and in most of the cases benign in nature. Phototherapy (PT) is one of the most common noninvasive methods of treatment. There are few studies on effect of phototherapy on platelet count with contrsting results. So, this study was done to see the effects of conventional phototherapy on platelet counts. Study group consisted of 100 consecutive neonates with hyperbilirubiemia. Serum bilirubin and CBC with Platelet count was performed before starting PT, Twenty four hours (24Hrs) after PT and fourtyeight hours (48 hrs) after PT or at discontinuation of PT whichever was earlier. The platelet count before starting PT was considered as the control value for respective neonate. All the data analyzed using SPSS software (version 21) and compared with paired samples T test. A Total of 100 neonates with indirect hyperbilirubinemia were enrolled in the study of which 58 (58 %) were males and 48 (48%) were females. For Preterm neonates mean Platelet Count was decreased 24 Hr after Phototherapy when compared with the Platelet Count before starting Phototherapy which was statistically significant ( p = 0.018 ).When entire study population was studied as a whole, it was found that the Mean Platelet Count 24 Hr after Phototherapy was decreased as compared to the Mean Platelet Count before starting Phototherapy which was also statistically significant ( p = 0.008).Our study proves that Phototherapy in newborns with Indirect Hyperbilirubinemia leads to decrease in platelet count .This fall in Platelet Count is more significant in Preterm neonates.
Keywords: Phototherapy, Indirect Hyperbilirubinemia, Platelet Count.
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