Title: To Correlate of Clinical and Biochemical Profile of the Uremic Patients: A Prospective Study

Author: Dr H.S. Chhabra

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i3.102

Abstract

Background: In spite of extensive work on uremia until today the exact etiopathological agent responsible for the clinical toxicity of uremia could not be single out. Considering the sparsity of such studies which are a few in India and an attempt will be made to correlate them with clinical and biochemical profile of the uremic patients.

Material & Methods: A prospective study done on 25 cases of uremia due to varied etiology were selected from the wards of general hospital, Dungarpur, Rajasthan. The cases were diagnosed on the basis of the criteria laid down by Jean Hamburger, Richet G. et al (1968). Cases were considered to be having renal failure if their blood urea level was over 50 mg% of these, those having urine output below 400 ml per 24 hour were grouped as cases of acute renal failure and those having urine output 400 ml were grouped as having chronic renal failure.

Results: Our study showed that maximum no. of cases (52%) affected were from the range of 31-50 years, males were more preponderance as compared to females. In biochemical analysis, the blood urea and serum Creatinine was higher and serum sodium & potassium within normal range. Out of 25 cases, 16 were alert and 9 cases were drowsy. Drowsy patients had elevated urea, Creatinine, and potassium levels and less sodium level as compared to alert patients.

Conclusion: We concluded that the blood urea and serum Creatinine was higher and serum sodium & potassium within normal range. Hyponatremia and patients with blood urea above 201 mg% had relatively less significant positive correlation.

Keywords: Uremia, Serum urea, Biochemical analysis, Serum Creatinine, serum sodium, serum potassium.

References

  1. Brenner B.M. & Rector F.C; Chronic renal failure. The Kidney, Saunders; 1976; Section 4:1423-1480.
  2. Merrill J.P.; Observation on the role of urea in uremia. American J. Medicine, 1953;14:519-520.
  3. Posner JB & Plum F. Spinal fluid pH & neurological symptoms in acidosis. New England Journal of Medicine, 1967;277:605-613.
  4. Hamburger Jean et al; Nephrology, Saunders, 1968;vol. 1:275-362.
  5. Schreiner, GR. Mental & personality changes in uremic syndrome. Medical annals D.C. 1957;28:316-329.
  6. Tyler H.R. Neurological disorders in renal failure. American Journal Medicine, 1968;44:734-738.
  7. Quastel J.H. & Scholifield; Biochemical aspects of cerebral dysfunction. American J. Medicine,1958.
  8. Balslor JJ & Jorgensen HE; A survey of 499 patients with acute anuric renal insufficiency. American J. Med. 1965;34:753.

Corresponding Author

Dr H.S. Chhabra

Principal Specialist (MD, Medicine),

PDDU Government Hospital, Sagwara (Dungarpur)

Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Mob. No. 9414497636