Title: Methicillin-Resistant Staphylococcus aureus Screening in Elective Surgery Patients in CCMMC Hospital Durg

Authors: Dr Subhasis Mandal, Dr Rolly Kaushik

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i3.68

Abstract

Background: Surgical site infection (SSI) is a major contributor of healthcare associated infection. Staphylococcus aureus is a pathogen responsible for both community-acquired as well as hospital-associated infections. SSI is associated with substantial increased of postoperative hospital stay, rates of hospital readmission, hospital cost, functional disability, and mortality rate. Patients in hospitals which are infected and colonized mediate the dissemination of (Methicillin Resistant Staphylococcus aureus) MRSA strains. Therefore it is necessary to know the prevalence of MRSA and its antibiotic sensitivity pattern for proper treatment of the patients and thereby reducing the morbidity and mortality of the patients.

Methods: The cross sectional study was conducted in CCMMC Durg. All adult patients admitted to the hospital and assigned for an elective surgery were chosen to collect data on MRSA. Swabs were taken from the anterior nares and axilla. Antibiotic susceptibility testing was performed by the disk diffusion method using guidelines established by the Clinical and Laboratory Standards Institute (CLSI) and MRSA was detected by testing with Cefoxitin disc

Results: A total of 121 patients (42.6%) were colonized with Staphylococcus epidermidis and 59 patients (20.77%) had positive nasal swabs for Methicillin-Sensitive Staphylococcus aureus (MSSA) and 24 (8.45%) patients were Methicillin-Resistant Staphylococcus aureus (MSSA).

Conclusion: MRSA strains are more prevalent in tertiary care hospital and multidrug resistant MRSA prevalence is higher in surgical units. Selective swabbing and decolonization for high risk preoperative patients may be more appropriate. The most effective way to prevent MRSA is surveillance of antibiotic resistance profiles of Staphylococcus aureus and there should be formulation of antibiotic policy in the hospital. Thus, control of MRSA is essential to curtail the introduction and spread of infection in the hospitals. This can be achieved by using universal precautions and conducting regular epidemiological studies.

References

  1. Centers for Disease Control and Prevention. HAI data and statistics. In: Healthcare-associated infections. CDC. 20 Apr 2016.
  2. Cavalcanti SM, França ER, Cabral C, Vilela MA, Montenegro F, Menezes D, Medeiros AC Braz J. Prevalence of Staphylococcus aureus introduced into intensive care units of a University Hospital. Infect Dis. 2005 Feb; 9(1):56-63.
  3. Tiwari HK, Das AK, Sapkota D, Sivrajan K, Pahwa VK .Methicillin resistant Staphylococcus aureus: prevalence and antibiogram in a tertiary care hospital in western Nepal.J Infect Dev Ctries. 2009 Oct 22; 3(9):681-4.
  4. Stefani S, Chung DR, Lindsay JA, Friedrich AW, Kearns AM, Westh H, Mackenzie FM. Meticillin-resistant Staphylococcus aureus(MRSA): global epidemiology and harmonisation of typing methods. Int J Antimicrob Agents. 2012;39(4):273–282.
  5. Reichman DE, Greenberg JARev. Reducing surgical site infections: a review. Obstet Gynecol. 2009 Fall; 2(4):212-21.
  6. Bebko SP, Green DM, Awad SS Effect of a preoperative decontamination protocol on surgical site infections in patients undergoing elective orthopedic surgery with hardware implantation. JAMA Surg. 2015 May; 150(5):390-5.
  7. Kim DH, Spencer M, Davidson SM, Li L, Shaw JD, Gulczynski D, Hunter DJ, Martha JF, Miley GB, Parazin SJ, Dejoie P, Richmond JC Institutional prescreening for detection and eradication of methicillin-resistant Staphylococcus aureus in patients undergoing elective orthopaedic surgery. J Bone Joint Surg Am. 2010 Aug 4; 92(9):1820-6.
  8. Roth VR, Longpre T, Coyle D, Suh KN, Taljaard M, Muldoon KA, Ramotar K, Forster A Cost Analysis of Universal Screening vs. Risk Factor-Based Screening for Methicillin-Resistant Staphylococ-cus aureus (MRSA). PLoS One. 2016; 11(7):e0159667.
  9. Lowy FD Staphylococcus aureus infections. NEngl J Med. 1998 Aug 20; 339(8):520-32.
  10. Rajaduraipandi K, Mani KR, Panneerselvam K, Mani M, Bhaskar M, Manikandan P.Prevalence and antimicrobial susceptibility pattern of methicillin resistant Staphylococcus aureus: a multicentre study.Indian J Med Microbiol. 2006 Jan; 24(1):34-8.
  11. Anupurba S, Sen MR, Nath G, Sharma BM, Gulati AK, MohapatraTM.Prevalence of methicillin resistant Staphylococcus aureus in a tertiary referral hospital in eastern Uttar Pradesh. Indian J Med Microbiol. 2003 Jan-Mar; 21(1):49-51.
  12. Vidhani S, Mehndiratta PL, Mathur MD.Study of methicillin resistant S. aureus (MRSA) isolates from high risk patients. Indian J Med Microbiol. 2001 Apr-Jun; 19(2):13-6.
  13. Clinical and Laboratory Standards Institute (CLSI). M100-S25 Performance standards for antimicrobial susceptibility testing; Twenty-fifth informational supplement. Wayne: Clinical and Laboratory Standards Institute; 2015.
  14. Sader HS, Farrell DJ, Jones RN, Antimicrobial susceptibility of Gram-positive cocci isolated from skin and skin-structure infections in European medical centres. Int J Antimicrob Agents. 2010 Jul; 36(1):28-32.
  15. Oh ML, Tan SY. P054: Prevalence and risk factor analysis for methicillin-resistant Staphylococcus aureuscoloniza-tion in an acute care hospital. Antimicrob Resist Infect Control. 2013;2:P54. doi: 10.1186/2047-2994-2-S1-P54
  16. Rajaduraipandi K, Mani KR, Panneerselvam K, Mani M, Bhaskar M, Manikandan P.Prevalence and antimicrobial susceptibility pattern of methicillin resistant Staphylococcus aureus: a multicentre study.Indian J Med Microbiol. 2006 Jan; 24(1):34-8.
  17. Majumder D, Bordoloi JS, Phukan AC, Mahanta. Antimicrobial susceptibility pattern among methicillin resistant Staphylococcus isolates in Assam. Majumder D, Bordoloi JS, Phukan AC, Mahanta JIndian J Med Microbiol. 2001 Jul-Sep; 19(3):138-40.
  18. adley S, Immerman I, Hutzler L, Slover J, Bosco J. Staphylococcus aureus decolonization protocol decreases surgical site infections for total joint replacement.  2010.
  19. Apoor R, Barnett CJ, Gutmann RM, Yildiz VO, Joseph NC, Stoicea N, et al. Preoperative prevalence of Staphylococcus aureusin cardiothoracic and neurological surgical patients. Front Public Health. 2014;2:204.
  20. Anderson MJ, David ML, Scholz M, Bull SJ, Morse D, Hulse-Stevens M, et al. Efficacy of skin and nasal povidone-iodine preparation against mupirocin-resistant methicillin-resistant Staphylococcus aureusand  aureus within the anterior nares. Antimicrob Agents Chemother. 2015.
  21. Assadullah S, Kakru DK, Thoker MA, Bhat FA, Hussain N, Shah A. Emergence of low level vancomycin resistance in MRSA. Indian J Med Microbiol. 2003 Jul-Sep; 21(3):196-8.

Corresponding Author

Dr Rolly Kaushik

Assistant Professor Dept. of Anatomy,

CCM Medical College Kachandur, Durg (CG), India