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Category: Volume 06 Issue 03 March 2018
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Title: To Evaluate Qualitative and Quantitative Changes of Corneal Endothelial Cells in Pseudoexfoliation Syndrome

Authors: Dr P.C. Dhaka, Dr F.H. Gauri, Dr Nusrat Gauri

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i3.11

Abstract

Background: PEX syndrome significantly influences cell density of corneal endothelium of people with this disease. The clinical uses of cell analysis include the assessment of donor corneal endothelium, effects of intraocular surgery and is essential in evaluating the safety of corneal surgical procedure. The aim of present study to evaluated the qualitative and quantitative changes of corneal endothelial cells in pseudoexfoliation syndrome.

Material & Methods: The present study was conducted in Department of Ophthalmology, Government B.D. hospital, Churu, Rajasthan. This was randomized and single site study to evaluate qualitative and quantitative changes of corneal endothelial cells in pseudoexfoliation syndrome with or without glaucoma by specular microscopy in Indian study population. We included 40 patients and randomized them in to 2 groups of 20 patients each as follows: Group A having Young healthy person serving as control group and Group B having psuedoexfolation syndrome group.

Results: Our study showed that the maximum subjects (n=15) in 55-65 years in age in control group and 8 patients in 66-75 years in age in psuedoexfoliation syndrome group. Male to female ratio was 3:2 in control group and 1.22:1 in PSX group. The mean value of endothelial cell density (cells/mm2) in normal subjects were 2511±171.3 and compare to mean value (2124±116.0) of psuedoexfolation syndrome group was statistically significant (p<0.0001***), cell size variation coefficient in psuedoexfolation syndrome group was statistically significant (p<0.0001***), The hexagonalty (%) statistically significant (p<0.0001***), but Central corneal thickness (µm) in normal subjects were 530.8±26.20 and compare to mean value (524.8±16.19) of psuedoexfolation syndrome group was statistically insignificant (p=0.3892 NS).

Conclusion: This study confirms the existence of qualitative and quantitative modifications in endothelial cells of eyes with PEX, particularly when IOP is high. It could also indicate a possible independent biological role of CCT as a risk factor for the development of glaucoma in subjects with PXS.

Keywords: Psuedoexfoliation syndrome, Center corneal thickness, Intraocular pressure, Hexagonalty.

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Corresponding Author

Dr. F.H. Gauri

Principal Specialist (M.D. Medicine),

Government D.B. General Hospital, Churu, Rajasthan

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