Title: A Study on Clinical Profile and Laboratory Diagnosis of Dengue Patients
Authors: Shilpi Hora, Archana Garg, Sita Shivram, Manish Pokra, Ramjilal Meena
DOI: https://dx.doi.org/10.18535/jmscr/v6i2.212
Abstract
Background: Dengue is a highly endemic infectious disease of tropical countries and is rapidly becoming a global burden. It is clinically similar to many other acute febrile illnesses, in which serological test plays an important role in early diagnosis and management. The spectrum of illness is broad and ranges in severity from mild symptoms to death. Changes in dengue epidemiology and increase in incidence rates (with and without co-morbidities) have lead WHO to propose a new dengue classification system according to disease severity.
Objective: The study was aimed at determining the seropositivity in clinically suspected dengue cases and also to study the clinical profile of dengue positive patients.
Materials and Methods: In this study, 2968 patients with Pyrexia of unknown origin (PUO) were included .Rapid Card test and Enzyme Linked Immunosorbent Assay (ELISA) were used for testing serum of patients.
Results: Of 2968, 521 were clinically suspected cases of dengue. 228 were confirmed to have dengue. Based on the 228 serological positive test, 126 (55%) were with dengue with warning signs followed by 74 (33%) dengue without warning signs and severe dengue 28 (12%)
Conclusion: Dengue fever continues to be a major public health problem. The study showed that 521 were clinically suspected cases of dengue and 228 were confirmed to have dengue. The study highlights that in most dengue endemic countries, access to diagnostic laboratories is limited and dengue diagnosis may rely solely on clinical recognition. Moreover, even where diagnostic laboratory services are available, virological tests are requested only upon a clinical suspicion of dengue, based on the presenting symptoms and signs.
Keywords: Dengue fever, new dengue classification, Pyrexia of unknown origin (PUO),Seropositivity.
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