Title: Preeclampsia is Associated with Elevated Iron and Ferritin in Third Trimester of Pregnancy: A Cross Sectional Observational Study from A Tertiary Center At Kolkata
Authors: Sangeeta Jana (Pramanik), Mousumi Mukhopadhyay, Sambhu Nath Bandyopadhyay, Tamoghna Jana, Subhodip Pramanik
DOI: https://dx.doi.org/10.18535/jmscr/v6i2.184
Abstract
Preeclampsia is one of the leading cause of maternal mortality during pregnancy. Generation of reactive oxygen species (ROS) in presence of catalytic amount of iron has been implicated into one of its pathogenesis. The objective of this study was to compare iron status (Iron, Ferritin, Total iron binding capacity [TIBC] and Transferrin saturation) between preeclamptic and normotensive-nonproteinuric pregnant women. In this observational cross sectional study, 80 pregnant women (40 normotensive-nonproteinuric and 40 pre-eclamptic pregnant women of age ranging between 18-35 years and having gestational age between 28 to 36 weeks were recruited. Serum concentrations of iron and TIBC were estimated using Randox Daytona Access Auto analyser. Ferritin was measured by Enzyme Linked Immuno Assay and percentage Transferrin saturation was done by calculation. The Mean± SD of Iron parameters in preeclamptic and non preeclamptic women were as follows: Iron 74.5± 24.8 vs 55.0 ± 13.1 µg/dl, p <0.001; Ferritin 70± 21.9 vs 44.7 ± 16.9 ng/ml, p< 0.001; Transferrin saturation 21.5± 9.1 vs 16.4 ± 9.3%, p<0.001 and TIBC365.5 ± 91.4 vs379.2 ± 111.7 µg/dl, p=0.408. None of the ferrokinetic parameters correlated with blood pressure. There was good correlation between serum iron and ferritin (r = 0.59, p= 0.001) and serum iron and serum percent transferrin saturation (r= 0.68, p= 0.001). To conclude, serum iron, ferritin, and transferrin saturation were significant higher in preeclamptic women as compared with non preeclamptic women in third trimester.
Keywords: Ferrokinetics in pregnancy, Eclampsia, Oxygen free radicals.
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