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Category: Volume 06 Issue 02 February 2018
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Title: A Randomized Controlled Study to Assess the Effect of Doxycycline on IL-6 and TNF Levels among the Patients of Dengue

Authors: Dr Nishant Kanodia MBBS MD Medicine, Dr Dinesh Chand Khare MBBS MD Medicine

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i2.168

Abstract

Objective: To evaluate the ability of doxycycline to modulate cytokines in patients with DF or DHF.

Methods: This was a randomized controlled trial conducted in a tertiary care hospital in north India. A total of 36 patients of DF or DHF were included in the study and randomized into 2 groups (18 in each group) by using computer generated random number table.  Blood samples were obtained from hospitalized patients 18–55 years of age presenting with symptoms characteristic of DF or DHF. In group A, for patients 18–55 years of age, an initial oral dose of 200 mg was followed by 100 mg administered at 12 hour intervals for 10 days. Patients of Group B were untreated. Cytokine levels were assessed at 0 day and 7 days by standard methods. 

Results: All patients demonstrated elevated IL-6 and TNF levels at day 0 evidenced by higher mean levels in both the groups. Over the 7-day observation period, IL-6 and TNF remained elevated in the control group (Group B). Treatment with doxycycline resulted in statistically (p=0.0001) lower levels of IL-6 and TNF by day 7, both when compared to that seen at day 0 (intragroup analysis) and when compared to day 0 values in the control group.  Decreases in Il-6 and TNF between day 0 and day 7 values were modest in the control group than treated with doxycycline (Group A). Treatment with doxycycline resulted in IL-6 and TNF levels being significantly (p=0.0001) lower than control group by day 7.

Conclusions: The findings from the current study indicate that doxycycline could be an effective treatment for dengue patients with high risk of complications.

Keywords: Doxycycline, Dengue, Cytokines.

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Corresponding Author

Dr Dinesh Chand Khare MBBS MD Medicine

Professor Department of Medicine, Hind Institute of Medical Sciences,

Safedabad, Lucknow UP India